The University of Naples Federico II (Italian: Università degli Studi di Napoli Federico II) is a university located in Naples, Italy. It was founded in 1224 and is organized into 13 faculties. It is the world's oldest state university and one of the oldest academic institutions in continuous operation.

Federico II is the third University in Italy by number of students enrolled, despite its huge dimensions it still represents one of the best Universities in Italy being an excellence in particular for research; in 2015 it was ranked among the first 100 universities in the world by citations per paper. The university is named after its founder Frederick II.