Viruses and human cancers

Viruses and human cancers

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  • From www.fun-mooc.fr
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  • Free Access
  • Free certificate
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  • 29 Sequences
  • Introductive Level
  • Starts on January 6, 2019
  • Ends on April 28, 2019

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Course details

Syllabus

Chapter 1 : Mechanisms of virus induced oncogenesis : direct/ Mécanismes directs de l’oncogenèse viro-induite

  • ntroduction/ntroduction
  • Origin of HIV and animal reservoirs/Mécanismes de l’oncogenèse virale
  • Mechanisms of viral oncogenesis/Mode de transmission et histoire naturelle de l’infection.
  • Mechanisms of oncogenesis. Pathogenesis and immune evasion/Mécanismes de l’oncogenèse, physiopathologie et évasion immune.
  • Human oncogenic viruses and centrosomes/Virus oncogènes humains et centrosomes.
  • Integration of viruses and cancers/Intégration des virus et cancers.

Chapter 2: Mechanisms of virus induced oncogeneis: indirect/ Mécanismes indirects de carcinogenèse virale

  • Inflammation and cancers /Inflammation et cancers.
  • Viruses, immunity and cancers/Virus, immunité et cancers.
  • Stress induced by viruses (or Viral stress), mutations and cancers/ Stress viral, mutations et cancers.
  • Interactome, viruses and cancer/Interactome, virus et cancers.

Chapter 3 :Retroviruses /Rétrovirus.

  • Epidemiology of HTLV-1/Epidémiologie du virus HTLV-1.
  • Viral oncogenesis as a subversion of viral multiplication/ L’oncogenèse virale comme subversion de la multiplication virale.
  • Mechanisms of mother to child transmission of the oncogenic virus HTLV-1/ mécanismes de la transmission du virus HTLV-1 de la mère à l’enfant.
  • Endogenous retroviruses/Les rétrovirus endogènes.

Chapter 4: Papillomaviruses/Papillomavirus/Papillomavirus

  • Epidemiology of human papillomaviruses/Epidémiologie du papillomavirus humain.
  • Human papilloma virus infection and disease/Infection par le papillomavirus chez l’homme et maladies encourues.
  • Oncogenic human papillomaviruses/ Le papilloma virus oncogène chez l’homme.
  • Merkel polyomavirus/Le polyomavirus de Merkel.

Chapter 5 : Hepatitis B and C viruses and hepatocellular carcinoma/ les virus de l’hépatite B et de l’hépatite C et le carcinome hépatocellulaire.

  • Epidemiology of HBV/HCV related HCC/Epidémiologie du carcinome cellulaire du virus de l’hépatite B et du virus de l’hépatite C.
  • Mechanisms of HBV/HCV-induced HCC/Mécanismes de la cancérogenèse hépatique induite par les virus de l’hépatite B et le virus de l’hépatite C.
  • HBV-HCV/HIV related HCC/CHC chez les coinfectés HIV/HBV-HCV
  • Universal hepatitis B vaccination: a way to eliminate hepatocellular carcinoma?/La vaccination anti VHB universelle: un moyen d’éliminer le carcinome hépatocellulaire?
  • Modeling hepatitis virus infections and treatment strategies in humanized mice/Modélisation de l’infection par les hépatites et des stratégies thérapeutiques chez la souris humanisée?

Chapter 6 : Herpes viruses/Virus de l’herpès /Virus de l’herpès

  • Oncogenic gamma-herpesviruses/Le virus gamma de l’herpès.
  • Herpesviruses, general introduction/Introduction générale sur le virrus de l’herpès.
  • Epidemiology of HHV8/Epidémiologie du virus HHV8.
  • Kaposi’s sarcoma and HHV8/Le sarcome de Kaposi et le virus HHV8.

Chapter 7 : Prevention and vaccination/Prévention et vaccination

  • Therapeutic DNA vaccine against cancer/ Vaccin ADN thérapeutique contre le cancer.
  • Oncolytic viruses : a new class of immunotherapeutic drugs/ Les virus oncolytiques : une nouvelle classe de médicaments d’immunothérapie.

Prerequisite

TWe recommend a good scientific background (such as a bachelor of science)./ Un bon niveau scientifique est recommandé pour suivre ce MOOC (licence en sciences).

Instructors

Jean-Pierre Vartanian
Jean-Pierre Vartanian is Associate Professor at Institut Pasteur and Team Leader of the Molecular Retrovirology Unit. He is the co-director of the Fundamental Virology course at the Institut Pasteur. His work is focused on identifying restriction factors involved in viral replication and the role of cellular RNA/DNA editing enzymes with antiviral activity against a range of human pathogens.

Editor

The Institut Pasteur is a private, not-for-profit French foundation based in Paris, dedicated to the study of biology, micro-organisms, diseases and vaccines.

Created in 1888 thanks to an international public subscription, it is named after Louis Pasteur1, its founder and first director, who in 1885 developed the first vaccine against rabies.

For over a century, the Institut Pasteur has been at the forefront of the fight against infectious diseases. In 1983, this international research organisation was the first to isolate the human immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS). Over the years, it has been responsible for revolutionary discoveries that have enabled medicine to control virulent diseases such as diphtheria, tetanus, tuberculosis, poliomyelitis, influenza, yellow fever, epidemic plague, hepatitis B and AIDS.

Platform

France Université Numérique is the broadcaster of the online courses of French higher education institutions and their partners.

It operates several platforms of diffusion, of which the best known, FUN MOOC, is the first French-speaking academic platform worldwide. Thanks to many partner institutions, this platform offers a vast catalog of courses enriched daily with various themes and current events.

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