- De www.coursera.org
Genomic Data Science Capstone
- Individualizado
- Acesso livre
- Certificado pago
- 10 sequências
- Introductive Level
Detalhes do curso
Programa de Estudos
- Week 1 - Introduction
In this first week, we'll introduce the project and get you oriented to the tasks that you'll be performing over the next several weeks. - Week 2 - Introduction to the Dataset - Andrew Jaffe
This week, we'll really dig into the dataset by providing an introduction from Andrew Jaffe, the lead scientist on the analysis. You should also be looking ahead to Task 2, which is due in Week 4; the alignment will take a long time to perform, so you should s... - Week 3 - Understand the Problem
The purpose of genomic data science is to answer fundamental questions in biology. Before starting on the data analysis process, the first step is always to understand the scientific question you are trying to answer. Don't forget to stay on top of the alignme... - Week 4 - Alignment
Once you have understood the problem, the next step is to obtain the raw data so that you can perform your analysis. - Week 5 - QC the Alignment
Now you have aligned the data, the next step is to do some quality control to make sure that the data are in good shape. - Week 6 - Get Feature Counts
Now that you have performed alignment and quality control, the next step is to calculate the abundance of every gene in every sample. - Week 7 - Exploratory Analysis
After summarizing your genomic data the next step is to load the data into R for analysis with Bioconductor. - Week 8 - Statistical Analysis
The next step is to perform a statistical analysis to detect genes that are differentially expressed. - Week 9 - Gene Set Analysis
In task 6, we have identified genes differentially expressed between fetal and adult brain. Now we will examine these results in a wider context. - Week 10 - Describe Your Analysis
The next step is to document your work. One of the major issues in genomic data science is that there are so many steps in the process. If these steps are not documented well the result can be major problems.
Pré-requisito
Instrutores
Jeff Leek, PhD
Associate Professor, Biostatistics
Bloomberg School of Public Health
Kasper Daniel Hansen, PhD
Assistant Professor, Biostatistics and Genetic Medicine
Bloomberg School of Public Health
Editor
A Universidade Johns Hopkins (JHU) é uma universidade privada americana situada em Baltimore, Maryland. Tem também campus em Washington, D.C., Bolonha, Itália, Singapura e Nanjing, China. Deve o seu nome a Johns Hopkins, um rico empresário que legou 7 milhões de dólares à universidade aquando da sua morte.
Uma das universidades mais prestigiadas dos Estados Unidos (nomeadamente pelas suas faculdades de medicina e de saúde pública, bem como pela sua escola de assuntos internacionais), a instituição define-se como a principal "universidade de investigação" do país. No início da sua história, inspirou-se principalmente na Universidade de Heidelberg e no modelo educativo alemão de Wilhelm von Humboldt. Em 2019, 39 vencedores do Prémio Nobel têm os seus nomes associados à universidade.
Plataforma
A Coursera é uma empresa digital que oferece um curso on-line massivo e aberto, fundado pelos professores de computação Andrew Ng e Daphne Koller Stanford University, localizado em Mountain View, Califórnia.
O Coursera trabalha com as melhores universidades e organizações para disponibilizar alguns dos seus cursos on-line e oferece cursos em várias disciplinas, incluindo: física, engenharia, humanidades, medicina, biologia, ciências sociais, matemática, negócios, ciência da computação, marketing digital, ciência de dados. e outros assuntos.Cours