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来源：www.coursera.org
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等级：入门
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疾病与疾病
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语言：英语
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264分
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33小时总数
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Introductory virology course emphasizing the common reactions that must be completed by all viruses for successful reproduction within a host cell.
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课程大纲
Week 1
Welcome to virology
What is a virus?
Viruses then and now
Week 2
The infectious cycle
Assay of viral infectivity
Measurement of virions and their components
Revolutionary methods
One-step growth cycle
Welcome to virology
What is a virus?
Viruses then and now
Week 2
The infectious cycle
Assay of viral infectivity
Measurement of virions and their components
Revolutionary methods
One-step growth cycle
Week 3
The Baltimore scheme
DNA virus genomes
RNA virus genomes
Viral genetics
The Baltimore scheme
DNA virus genomes
RNA virus genomes
Viral genetics
Week 4
Structure
The tools of structural virology
Helical symmetry
Icosahedral symmetry
Enveloped virions
Complex virions
Structure
The tools of structural virology
Helical symmetry
Icosahedral symmetry
Enveloped virions
Complex virions
Week 5
Attachment to cells
Entry into cells
Acid-catalyzed fusion
A new paradigm for entry
Entry of non-enveloped virions
Entering the nucleus
Attachment to cells
Entry into cells
Acid-catalyzed fusion
A new paradigm for entry
Entry of non-enveloped virions
Entering the nucleus
Week 6
Viral RNA synthesis
RNA polymerization
Plus strand RNA synthesis
Negative strand RNA synthesis
RNA synthesis of dsRNA genomes
RNA synthesis as a source of diversity
Viral RNA synthesis
RNA polymerization
Plus strand RNA synthesis
Negative strand RNA synthesis
RNA synthesis of dsRNA genomes
RNA synthesis as a source of diversity
Week 7
DNA basics
Lessons from SV40
Priming via DNA or protein
Viral origins
Big DNA viruses
Regulation of DNA synthesis
DNA basics
Lessons from SV40
Priming via DNA or protein
Viral origins
Big DNA viruses
Regulation of DNA synthesis
Week 8
Transcription
Initiation of transcription
Viral transcription regulation
Capping and polyadenylation
Pre-mRNA splicing
Transcription
Initiation of transcription
Viral transcription regulation
Capping and polyadenylation
Pre-mRNA splicing
Week 9
Reverse transcriptase
Retroviruses
Reverse transcription
Integration
The provirus
Hepatitis B virus
Reverse transcriptase
Retroviruses
Reverse transcription
Integration
The provirus
Hepatitis B virus
Week 10
End-dependent initiation of protein synthesis
Other decoding mechanisms
One mRNA, one protein?
Maximizing coding capacity of the viral genome
Regulation of translation: eIF2alpha
How viruses regulate cell translation
MicroRNAs
End-dependent initiation of protein synthesis
Other decoding mechanisms
One mRNA, one protein?
Maximizing coding capacity of the viral genome
Regulation of translation: eIF2alpha
How viruses regulate cell translation
MicroRNAs
Week 11
Principles of virion assembly
Getting to the right place
Making sub-assemblies
Concerted assembly: Budding
Genome packaging
Acquisition of an envelope and egress
Principles of virion assembly
Getting to the right place
Making sub-assemblies
Concerted assembly: Budding
Genome packaging
Acquisition of an envelope and egress
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- Vincent Racaniello
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哥伦比亚大学是一所私立大学，位于美国纽约曼哈顿区西北部的晨边高地。它起源于 1754 年由英国国王乔治二世创建的国王学院。哥伦比亚大学是美国历史最悠久的高等学府之一，也是常春藤联盟（Ivy League）的成员之一，常春藤联盟由美国历史最悠久、最著名、最有声望和最精英化的八所大学组成。
哥伦比亚大学是世界上最挑剔、最负盛名的大学之一。2019 年的录取率为 5.1%，与哈佛大学和斯坦福大学相当。其研究水平在美国排名第一，在CUWR世界千强大学排名中位列世界第六（美国第四），在上海大学排名中位列第八。
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Coursera是一家数字公司，提供由位于加利福尼亚州山景城的计算机教师Andrew Ng和达芙妮科勒斯坦福大学创建的大型开放式在线课程。
Coursera与顶尖大学和组织合作，在线提供一些课程，并提供许多科目的课程，包括：物理，工程，人文，医学，生物学，社会科学，数学，商业，计算机科学，数字营销，数据科学 和其他科目。
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