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来源：www.coursera.org
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等级：入门
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疾病与疾病
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语言：英语
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264分
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33小时总数
关于内容
Introductory virology course emphasizing the common reactions that must be completed by all viruses for successful reproduction within a host cell.
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课程大纲
Week 1
Welcome to virology
What is a virus?
Viruses then and now
Week 2
The infectious cycle
Assay of viral infectivity
Measurement of virions and their components
Revolutionary methods
One-step growth cycle
Welcome to virology
What is a virus?
Viruses then and now
Week 2
The infectious cycle
Assay of viral infectivity
Measurement of virions and their components
Revolutionary methods
One-step growth cycle
Week 3
The Baltimore scheme
DNA virus genomes
RNA virus genomes
Viral genetics
The Baltimore scheme
DNA virus genomes
RNA virus genomes
Viral genetics
Week 4
Structure
The tools of structural virology
Helical symmetry
Icosahedral symmetry
Enveloped virions
Complex virions
Structure
The tools of structural virology
Helical symmetry
Icosahedral symmetry
Enveloped virions
Complex virions
Week 5
Attachment to cells
Entry into cells
Acid-catalyzed fusion
A new paradigm for entry
Entry of non-enveloped virions
Entering the nucleus
Attachment to cells
Entry into cells
Acid-catalyzed fusion
A new paradigm for entry
Entry of non-enveloped virions
Entering the nucleus
Week 6
Viral RNA synthesis
RNA polymerization
Plus strand RNA synthesis
Negative strand RNA synthesis
RNA synthesis of dsRNA genomes
RNA synthesis as a source of diversity
Viral RNA synthesis
RNA polymerization
Plus strand RNA synthesis
Negative strand RNA synthesis
RNA synthesis of dsRNA genomes
RNA synthesis as a source of diversity
Week 7
DNA basics
Lessons from SV40
Priming via DNA or protein
Viral origins
Big DNA viruses
Regulation of DNA synthesis
DNA basics
Lessons from SV40
Priming via DNA or protein
Viral origins
Big DNA viruses
Regulation of DNA synthesis
Week 8
Transcription
Initiation of transcription
Viral transcription regulation
Capping and polyadenylation
Pre-mRNA splicing
Transcription
Initiation of transcription
Viral transcription regulation
Capping and polyadenylation
Pre-mRNA splicing
Week 9
Reverse transcriptase
Retroviruses
Reverse transcription
Integration
The provirus
Hepatitis B virus
Reverse transcriptase
Retroviruses
Reverse transcription
Integration
The provirus
Hepatitis B virus
Week 10
End-dependent initiation of protein synthesis
Other decoding mechanisms
One mRNA, one protein?
Maximizing coding capacity of the viral genome
Regulation of translation: eIF2alpha
How viruses regulate cell translation
MicroRNAs
End-dependent initiation of protein synthesis
Other decoding mechanisms
One mRNA, one protein?
Maximizing coding capacity of the viral genome
Regulation of translation: eIF2alpha
How viruses regulate cell translation
MicroRNAs
Week 11
Principles of virion assembly
Getting to the right place
Making sub-assemblies
Concerted assembly: Budding
Genome packaging
Acquisition of an envelope and egress
Principles of virion assembly
Getting to the right place
Making sub-assemblies
Concerted assembly: Budding
Genome packaging
Acquisition of an envelope and egress
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教师
- Vincent Racaniello
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For more than 250 years, Columbia has been a leader in higher education in the nation and around the world. At the core of our wide range of academic inquiry is the commitment to attract and engage the best minds in pursuit of greater human understanding, pioneering new discoveries and service to society.
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Coursera是一家数字公司，提供由位于加利福尼亚州山景城的计算机教师Andrew Ng和达芙妮科勒斯坦福大学创建的大型开放式在线课程。
Coursera与顶尖大学和组织合作，在线提供一些课程，并提供许多科目的课程，包括：物理，工程，人文，医学，生物学，社会科学，数学，商业，计算机科学，数字营销，数据科学 和其他科目。
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