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The objective of this course is to give students the most up-to-date information on the biological, personal, and societal relevance of sleep. Personal relevance is emphasized by the fact that the single best predictor of daytime performance is the quality of the previous night's sleep. The brain actively generates sleep, and the first section of the course is an overview of the neurobiological basis of sleep control. The course provides cellular-level understanding of how sleep deprivation, jet lag, and substances such as alcohol, ,caffeine, and nicotine alter sleep and wakefulness. The second section of the course covers sleep-dependent changes in physiology and sleep disorders medicine. Particular emphasis will be placed on disorders of excessive sleepiness, insomnia, and sleep-dependent changes in autonomic control. Chronic sleep deprivation impairs immune function and may promote obesity. Deaths due to all causes are most frequent between 4:00 and 6:00 a.m., and this second section of the class highlights the relevance of sleep for preventive medicine. The societal relevance of sleep will be considered in the final section of the class. In an increasingly complex and technologically oriented society, operator-error by one individual can have a disastrous negative impact on public health and safety. Fatigue-related performance decrements are known to have contributed as causal factors to nuclear power plant failures, transportation disasters, and medical errors.

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课程大纲

Section I – Neurobiology
Unit 01 - Course Overview - Ralph Lydic, Ph.D.
Unit 02 - Neurobiology of Sleep and Wakefulness - Helen Baghdoyan, Ph.D.
Unit 03 - Mathematical Modeling of Sleep-Wake Regulation - Victoria Booth, Ph.D.
Unit 04 - Molecular Biology and Genetics of Sleep - Chiara Cirelli, M.D., Ph.D.

Section II – Medicine
Unit 05 - Overview of Sleep Medicine - Ronald Chervin, M.D.
Unit 06 - Disordered Sleep and Breathing Alters Cardiovascular Health - Helena Schotland, M.D.
Unit 07 - Sleep and Psychiatric Disorders - Eric Nofzinger, M.D.
Unit 08 - Insomnia: Causes and Consequences - Christopher Drake, Ph.D.
Unit 09 - Treatments for Insomnia - J. Todd Arnedt, Ph.D.
Unit 10 - Sleep and Anesthesia - George Mashour, M.D.

Section III – Society
Unit 11 - Circadian Rhythms, Sleep, and Health - Theresa Lee, Ph.D.
Unit 12 - Daytime Sleepiness and Sleep Need - Thomas Roth, Ph.D.
 

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教师

Ralph Lydic, Ph.D.
Professor Emeritus, Molecular and Integrative Physiology, Professor Emeritus, Anesthesiology
University of Michigan Medical School

Helen Baghdoyan, Ph.D.
Professor Emeritus, Anesthesiology, Professor Emeritus, Pharmacology, Professor of Psychiatry
University of Michigan Medical School

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内容设计师

University of Michigan
The mission of the University of Michigan is to serve the people of Michigan and the world through preeminence in creating, communicating, preserving and applying knowledge, art, and academic values, and in developing leaders and citizens who will challenge the present and enrich the future.
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平台

Coursera

Coursera是一家数字公司,提供由位于加利福尼亚州山景城的计算机教师Andrew Ng和达芙妮科勒斯坦福大学创建的大型开放式在线课程。

Coursera与顶尖大学和组织合作,在线提供一些课程,并提供许多科目的课程,包括:物理,工程,人文,医学,生物学,社会科学,数学,商业,计算机科学,数字营销,数据科学 和其他科目。

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最佳评论

Very good course! I liked it a lot not only on professional perspective, but also personally to understand the importance of a good sleep and how everything is related.

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发布于 2018年3月4日
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发表于 2018年3月4日
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Very good course! I liked it a lot not only on professional perspective, but also personally to understand the importance of a good sleep and how everything is related.

发表于 2018年2月13日
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interesting course. However, it did not, another sleep disorder called Klein Levin syndrome which disrupts the thalamus in the brain that controls sleep. This causes the sufferer to sleep for months at a time or long extended period of time, causing disturbing sleep, increased appetite and an inability to wake up properly.

发表于 2018年1月3日
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Excellent course! A great review on stuff I should have remembered but of course have forgotten as I've aged. My thanks to those organizing and teaching the course! Dr Quincy