Network Analysis in Systems Biology

Name: Network Analysis in Systems Biology
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Author: Icahn School of Medicine at Mount Sinai

课程

英语

60 时

来源

来自www.coursera.org

状况

自定进度
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10 序列
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课程详情

教学大纲

Week 1 - Course Overview and Introductions
The 'Introduction to Complex Systems' module discusses complex systems and leads to the idea that a cell can be considered a complex system or a complex agent living in a complex environment just like us. The 'Introduction to Biology for Engineers' module prov...
Week 2 - Topological and Network Evolution Models
In the 'Topological and Network Evolution Models' module, we provide several lectures about a historical perspective of network analysis in systems biology. The focus is on in-silico network evolution models. These are simple computational models that, based o...
Week 3 - Types of Biological Networks
The 'Types of Biological Networks' module is about the various types of networks that are typically constructed and analyzed in systems biology and systems pharmacology. This lecture ends with the idea of functional association networks (FANs). Following this ...
Week 4 - Data Processing and Identifying Differentially Expressed Genes
This set of lectures in the 'Data Processing and Identifying Differentially Expressed Genes' module first discusses data normalization methods, and then several lectures are devoted to explaining the problem of identifying differentially expressed genes with t...
Week 5 - Gene Set Enrichment and Network Analyses
In the 'Gene Set Enrichment and Network Analyses' module the emphasis is on tools developed by the Ma'ayan Laboratory to analyze gene sets. Several tools will be discussed including: Enrichr, GEO2Enrichr, Expression2Kinases and DrugPairSeeker. In addition, one...
Week 6 - Deep Sequencing Data Processing and Analysis
A set of lectures in the 'Deep Sequencing Data Processing and Analysis' module will cover the basic steps and popular pipelines to analyze RNA-seq and ChIP-seq data going from the raw data to gene lists to figures. These lectures also cover UNIX/Linux commands...
Week 7 - Principal Component Analysis, Self-Organizing Maps, Network-Based Clustering and Hierarchical Clustering
This module is devoted to various method of clustering: principal component analysis, self-organizing maps, network-based clustering and hierarchical clustering. The theory behind these methods of analysis are covered in detail, and this is followed by some pr...
Week 8 - Resources for Data Integration
The lectures in the 'Resources for Data Integration' module are about the various types of networks that are typically constructed and analyzed in systems biology and systems pharmacology. These lectures start with the idea of functional association networks (...
Week 9 - Crowdsourcing: Microtasks and Megatasks
The final set of lectures presents the idea of crowdsourcing. MOOCs provide the opportunity to work together on projects that are difficult to complete alone (microtasks) or compete for implementing the best algorithms to solve hard problems (megatasks). You w...
Week 10 - Final Exam
The final exam consists of multiple choice questions from topics covered in all of modules of the course. Some of the questions may require you to perform some of the analysis methods you learned throughout the course on new datasets.

先决条件

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讲师

Avi Ma’ayan, PhD
Director, Mount Sinai Center for Bioinformatics
Professor, Department of Pharmacological Sciences

编辑

The Icahn School of Medicine at Mount Sinai, formerly the Mount Sinai School of Medicine, is an American medical school in the borough of Manhattan in New York City. The Graduate School of Biomedical Sciences provides rigorous training in basic science and clinical research.