Davidson College
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assignment 等级:中级
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This medicinal chemistry course explores how chemists modify a molecule’s structure to design a safe and effective drug.

This course opens with a brief history of drug discovery and introduces the modern drug approval process.Then, we will transition to learning about receptors and enzymes, the body’s molecules most often targeted by drugs.We will also discuss the topics of pharmacokinetics (drug adsorption, elimination, and half-life) and metabolism. The course closes with units on how potential drug molecules are identified and subsequently optimized into safe and effective drugs.

  • How to measure the activity of enzymes and receptors
  • Methods for modeling a drug’s half-life
  • How to predict and alter the metabolism of a molecule
  • Techniques for discovering molecules with desired biological activity
  • Approaches for optimizing a molecule into a safe and effective drug

This course is offered through a collaboration between DavidsonX and the Novartis Institutes of BioMedical Research.

 

Courses offered via edX.org are not eligible for academic credit from Davidson College. A passing score in a DavidsonX course(s) will only be eligible for a verified certificate generated by edX.org.

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前提

High school level chemistry and biology and some experience with organic chemistry.
Basic math skills (logarithms and exponential functions) are also recommended.

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课程大纲

Week 1: Pre-Regulatory Medicine and the Drug Approval Process Early natural products and synthetic molecules used as drugs Safety issues in the first drugs Modern drug discovery and approval process Intellectual property issues with drugs  
Week 2: Drug Targets Structure of proteins Enzymes, enzymatic activity, and inhibition Receptors and molecules that modulate their activity Examination 1  
Week 3: Pharmacokinetics Drug transport in the blood Clearance Volume of distribution Compartment modeling  
Week 4: Metabolism Types of metabolic reactions Genetic and population effects Prodrugs Examination 2  
Week 5: Binding, Structure, and Diversity Intermolecular forces Drug-target complementarity Molecular diversity and chemical libraries Combinatorial chemistry  
Week 6: Lead Discovery Drug screening Filtering hits to find leads Existing drugs and natural products as leads  
Week 7: Lead Optimization Functional group replacements Alkyl group replacements Isosteres and bioisosteres Peptidomimetics Examination 3  
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教师

Erland Stevens
Faculty, Chemistry
Davidson College

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EdX est une plateforme d'apprentissage en ligne (dite FLOT ou MOOC). Elle héberge et met gratuitement à disposition des cours en ligne de niveau universitaire à travers le monde entier. Elle mène également des recherches sur l'apprentissage en ligne et la façon dont les utilisateurs utilisent celle-ci. Elle est à but non lucratif et la plateforme utilise un logiciel open source.

EdX a été fondée par le Massachusetts Institute of Technology et par l'université Harvard en mai 2012. En 2014, environ 50 écoles, associations et organisations internationales offrent ou projettent d'offrir des cours sur EdX. En juillet 2014, elle avait plus de 2,5 millions d'utilisateurs suivant plus de 200 cours en ligne.

Les deux universités américaines qui financent la plateforme ont investi 60 millions USD dans son développement. La plateforme France Université Numérique utilise la technologie openedX, supportée par Google.

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