Human Population and Evolutionary Genetics

Human Population and Evolutionary Genetics

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课程
en
英语
10 时
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来源
  • 来自www.fun-mooc.fr
更多信息
  • 5 序列
  • 等级 中级
  • 从16 十月 2023开始
  • 以5 十二月 2023结束

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课程详情

教学大纲

Chapter 1 – Human genome diversity and population genetics

  • Diversity of the human genome
  • Public databases of population genetic variation
  • Causes of genetic diversity: mutation and recombination
  • Factors driving genetic diversity: genetic drift
  • Factors driving genetic diversity: natural selection

Chapter 2 – The demographic history of human populations

  • Methods of demographic inference
  • Population splits and admixture among humans
  • The genetic history of the African continent
  • The genetic history of the European continent
  • The genetic history of Asia, Australia and Oceania
  • The genetic history of the Americas
  • The use of pathogens as markers of human migrations
  • Inferring cultural practices through genetics

Chapter 3 – The adaptive history of human populations

  • Diversity of the human genome
  • Methods to detect natural selection
  • The effects of purifying selection in the genome and populations
  • Adaptation to nutritional resources
  • Adaptation to climate and extreme conditions
  • Adaptation to pathogens and infectious diseases
  • Alternative models of adaptation

Chapter 4 – The contribution of ancient DNA studies to human evolution

  • Methods in ancient genomics
  • The archaic hominins and admixture with modern humans
  • Recent history through the lens of ancient DNA
  • The adaptive nature of archaic introgression
  • Public engagement and return to populations

 

 

先决条件

We recommend a good scientific background (such as a bachelor of live science).

讲师

Lluis Quintana-Murci
Lluis Quintana-Murci received his BSc in Biology at the University of Barcelona (Spain), and his Ph.D. in Population Genetics at the University of Pavia (Italy). He heads the Unit of Human Evolutionary Genetics at Institut Pasteur since 2007. He is a human population geneticist whose research focuses on the use of genomic data to infer the past demographic history of human populations and to dissect the different forms in which natural selection can act on the human genome. His team is especially interested in exploring the extent to which pathogens have exerted pressures on innate immunity genes. Over the last years, his team has also adopted a systems immunology approach to understand the different factors (genetic, epigenetic, environmental, etc.) that drive immune response variation between individuals and populations. Lluis Quintan-Murci is professor at College de France.

Etienne Patin
Etienne Patin received his MSc in Biology and Genetics and his PhD in Population Genetics at the University Paris VII (France). After a postdoctoral training in epidemiological genetics at the Necker Hospital (France), he joined Institut Pasteur as a CNRS Research Scientist. He is a population geneticist whose main interests range from the study of past human demography, with a focus on Africa, to the methodological aspects of demographic inference, and, more recently, systems immunology. One of his main research interests is the occurrence and extent of admixture between modern human populations and its potential adaptive nature.

Javier Mendoza Revilla
Javier is a doctor in human genetics, researcher in the Genetics of Human Evolution unit of the Pasteur Institute and member of the CANDELA consortium. He is your community manager for this MOOC.

编辑

巴斯德研究所(Institut Pasteur)是一家位于巴黎的非营利性法国私人基金会,致力于生物学、微生物、疾病和疫苗研究。

巴斯德研究所成立于 1888 年,由国际公众募捐建立,以其创始人和首任所长路易-巴斯德1 的名字命名,1885 年,巴斯德研制出第一支狂犬病疫苗。

一个多世纪以来,巴斯德研究所一直站在抗击传染病的最前沿。1983 年,这个国际研究机构率先分离出人类免疫缺陷病毒(HIV),即导致获得性免疫缺陷综合症(艾滋病)的病毒。多年来,该组织的革命性发现使医学得以控制白喉、破伤风、肺结核、脊髓灰质炎、流感、黄热病、流行性鼠疫、乙型肝炎和艾滋病等烈性疾病。

平台

France Université Numérique est le diffuseur des cours en ligne des établissements d’enseignement supérieur français et de leurs partenaires.

Il opère plusieurs plateformes de diffusion, dont la plus connue, FUN MOOC, est la première plateforme académique francophone mondiale. Grâce à de nombreux établissements partenaires, cette plateforme propose un vaste catalogue de cours s’enrichissant de jour en jour avec des thématiques variées et d’actualité.
 

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