关键信息
关于内容
Named a top 50 MOOC of all time by Class Central! This course begins a series of classes illustrating the power of computing in modern biology. Please join us on the frontier of bioinformatics to look for hidden messages in DNA without ever needing to put on a lab coat. In the first half of the course, we investigate DNA replication, and ask the question, where in the genome does DNA replication begin? We will see that we can answer this question for many bacteria using only some straightforward algorithms to look for hidden messages in the genome. In the second half of the course, we examine a different biological question, when we ask which DNA patterns play the role of molecular clocks. The cells in your body manage to maintain a circadian rhythm, but how is this achieved on the level of DNA? Once again, we will see that by knowing which hidden messages to look for, we can start to understand the amazingly complex language of DNA. Perhaps surprisingly, we will apply randomized algorithms, which roll dice and flip coins in order to solve problems. Finally, you will get your hands dirty and apply existing software tools to find recurring biological motifs within genes that are responsible for helping Mycobacterium tuberculosis go "dormant" within a host for many years before causing an active infection.
课程大纲
- Week 1 - Week 1: Welcome!
Welcome to class!
This course will focus on two questions at the forefront of modern computational biology, along with the algorithmic approaches we will use to solve them in parentheses:
- Weeks 1-2: Where in the Genome Does DNA Replication ...
- Week 2 - Week 2: Finding Replication Origins
Welcome to Week 2 of class!
This week, we will examine the biological details of how DNA replication is carried out in the cell. We will then see how to use these details to help us design an intelligent algorithmic approach looking for the replica...
- Week 3 - Week 3: Hunting for Regulatory Motifs
Welcome to Week 3 of class!
This week, we begin a new chapter, titled "Which DNA Patterns Play the Role of Molecular Clocks?" At the bottom of this message is this week's Bioinformatics Cartoon. What does a late night casino trip with two 18th...
- Week 4 - Week 4: How Rolling Dice Helps Us Find Regulatory Motifs
Welcome to Week 4 of class!
Last week, we encountered a few introductory motif-finding algorithms. This week, we will see how to improve upon these motif-finding approaches by designing randomized algorithms that can "roll dice" to find motifs.
- Week 5 - Week 5: Bioinformatics Application Challenge
Welcome to week 5 of the class! This week, we will apply popular motif-finding software in order to hunt for motifs in a real biological dataset.
教师
Pavel Pevzner
Professor
Department of Computer Science and Engineering
Phillip Compeau
Visiting Researcher
Department of Computer Science & Engineering
内容设计师
加州大学圣地亚哥分校是位于加利福尼亚州圣地亚哥的一所公立赠地研究型大学。加州大学圣地亚哥分校成立于 1960 年，位于斯克里普斯海洋学研究所附近，是加州大学十个校区中最南端的一个，提供 200 多个本科和研究生学位课程，在校本科生 33,096 人，研究生 9,872 人。
加州大学圣地亚哥分校被认为是世界上最好的大学之一。多份出版物将加州大学圣地亚哥分校的生物科学系和计算机科学系评为世界前十名。
平台
Coursera是一家数字公司，提供由位于加利福尼亚州山景城的计算机教师Andrew Ng和达芙妮科勒斯坦福大学创建的大型开放式在线课程。
Coursera与顶尖大学和组织合作，在线提供一些课程，并提供许多科目的课程，包括：物理，工程，人文，医学，生物学，社会科学，数学，商业，计算机科学，数字营销，数据科学 和其他科目。
