Finding Mutations in DNA and Proteins (Bioinformatics VI)

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Английский
24 h
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  • From www.coursera.org
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  • Self-paced
  • Free Access
  • Fee-based Certificate
More info
  • 6 Sequences
  • Introductive Level

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Course details

Syllabus

  • Week 1 - Week 1: Introduction to Read Mapping

    Welcome to our class! We are glad that you decided to join us.

    In this class, we will consider the following two central biological questions (the computational approaches needed to solve them are shown in parentheses):

    1. How Do We ...
    2. Week 2 - Week 2: The Burrows-Wheeler Transform

      Welcome to week 2 of the class!

      This week, we will introduce a paradigm called the Burrows-Wheeler transform; after seeing how it can be used in string compression, we will demonstrate that it is also the foundation of modern read-mapping algorithms...

    3. Week 3 - Week 3: Speeding Up Burrows-Wheeler Read Mapping

      Welcome to week 3 of class!

      Last week, we saw how the Burrows-Wheeler transform could be applied to multiple pattern matching. This week, we will speed up our algorithm and generalize it to the case that patterns have errors, which models the biolo...

    4. Week 4 - Week 4: Introduction to Hidden Markov Models

      Welcome to week 4 of class!

      This week, we will start examining the case of aligning sequences with many mutations -- such as related genes from different HIV strains -- and see that our problem formulation for sequence alignment is not adequate for ...

    5. Week 5 - Week 5: Profile HMMs for Sequence Alignment

      Welcome to week 5 of class!

      Last week, we introduced hidden Markov models. This week, we will see how hidden Markov models can be applied to sequence alignment with a profile HMM. We will then consider some advanced topics in this area, which are ...

    6. Week 6 - Week 6: Bioinformatics Application Challenge

      Welcome to the sixth and final week of class!

      This week brings our Application Challenge, in which we apply the HMM sequence alignment algorithms that we have developed.

Prerequisite

None.

Instructors

Pavel Pevzner
Professor
Department of Computer Science and Engineering

Phillip Compeau
Visiting Researcher
Department of Computer Science & Engineering

Editor

L' Université de Californie à San Diego est une université publique de recherche sur les concessions de terres à San Diego, en Californie. Établi en 1960 près de la Scripps Institution of Oceanography préexistante, l'UC San Diego est le plus méridional des dix campus de l' Université de Californie et offre plus de 200 programmes menant à un diplôme de premier cycle et des cycles supérieurs, recrutant 33 096 étudiants de premier cycle et 9 872 étudiants des cycles supérieurs. 

L'UC San Diego est considérée comme l'une des meilleures universités au monde. Plusieurs publications ont classé les départements de sciences biologiques et d'informatique de l'UC San Diego parmi les 10 meilleurs au monde.

Platform

Coursera - это цифровая компания, предлагающая массовые открытые онлайн-курсы, основанные учителями компьютеров Эндрю Нгом и Стэнфордским университетом Дафни Коллер, расположенные в Маунтин-Вью, штат Калифорния.

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