Vaccinology

Archived
Curso
en
Inglês
6 h
Este conteúdo é classificado como 0 de 5

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Fonte
  • De www.fun-mooc.fr
CONDIÇÕES
  • Acesso livre
  • Certificado gratuito
Mais informações
  • 32 sequências
  • Introductive Level
  • Começa em 4 dezembro 2016
  • Termina em 3 setembro 2019

You can't access an archived course

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Detalhes do curso

Programa de Estudos

Week 1: History - Basics
  • History of vaccines including IP
  • Smallpox eradication
  • Polio eradication
  • Modeling in vaccinology
  • Antigen discovery
Week 2: Basics (second part)
  • Immune memory of vaccines
  • Vaccines for pregnant women
  • Vaccines for neonates
  • Correlates of protection
  • Adjuvants
  • Delivery of vaccines
Week 3: Basics (end) - Preclinical and clinical development
  • On the importance of maintaining vaccine coverage
  • Epidemiology post vaccination: pertussis vaccine example
  • GMP production
  • Immuno-monitoring
  • Phase I/II clinical trials
  • Phase III clinical trials
Week 4: Recent success - New Vaccines made recently available - Improving existing vaccines
  • Success of glycoconjugate vaccines
  • Rotavirus vaccines
  • HPV vaccines
  • Influenza vaccines
  • TB vaccines
Week 5: Vaccines remaining to be developed and implemente
  • RSV vaccines
  • HIV vaccines
  • Malaria vaccines
  • Vaccines against neglected parasites and worms
Week 6: Future challenges
  • Innovation in future vaccines
  • Vaccines for the elderly
  • Vaccine economics
  • Globalization of vaccine production
  • Vaccine implementation on the field
  • Vaccine perception

Pré-requisito

Background in microbiology, immunology, public health

Connaissances en microbiology, immunology, santé publique.

Instrutores

Armelle Phalipon
Armelle Phalipon is a microbiologist leading a group within the Molecular Microbial Pathogenesis Unit, INSERM U786, at the Institut Pasteur, Paris, France. Working in the field of diarrheal diseases, her team is interested in deciphering the cross-talks between enteropathogenic bacteria and the host immune system. The main current studies aim at deciphering how Shigella, the bacterium responsible for bacillary dysentery, impacts on the development of the short-term, poorly effective protective immunity elicited in response to infection. Armelle Phalipon has a long-standing interest in combining fundamental and applied research. Indeed, in collaboration with Dr. Laurence Mulard (Institut Pasteur, Paris), she has designed a new type of Shigella vaccine candidate that will enter a phase 1 clinical trial in 2016 for proof of concept in humans. She is co-founder and co-director with Frédéric Tangy of the first International Vaccinology Course launched at the Pasteur Institute in 2008.

Frédéric Tangy
Frédéric Tangy, PhD, Dr.Sc., Director of Research at CNRS, is the head of the Viral Genomics and Vaccination Research Unit at Institut Pasteur, Paris (CNRS UMR-3569). After his PhD in 1980 and his Dr. Sc. in 1984 at Paris VI University he made his career as a virologist first at CNRS then at Institut Pasteur. He is co-director of the international Vaccinology course of Institut Pasteur, vice-president of the Scientific Council of Institut Pasteur, and member of ASM, ESGT, IAS, SFI. He is the author of 110 publications in international scientific journals and 19 international patents. In the recent years, he has developed two research programs: 1) generation of polyvalent viral attenuated vaccines based on a vector derived from measles vaccine. This project extends from the design of antigens and generation of recombinant vectors, to preclinical and clinical development in the field of HIV, dengue, chikungunya and malaria vaccines. 2) The second project investigates the interactions between viral and host proteins in a systematic way using functional genomic approaches such as high-throughput cloning, yeast two-hybrid, deep sequencing and high-throughput drug screening. This project aims at understanding at a molecular level the interactions between viral and host proteins and RNA in the field of paramyxoviruses. These observations lead to identify new drug targets and new determinants of pathogenicity/attenuation.

Editor

O Institut Pasteur é uma fundação francesa privada, sem fins lucrativos, com sede em Paris, dedicada ao estudo da biologia, dos microrganismos, das doenças e das vacinas.

Criado em 1888 graças a uma subscrição pública internacional, tem o nome de Louis Pasteur1, o seu fundador e primeiro diretor, que em 1885 desenvolveu a primeira vacina contra a raiva.

Durante mais de um século, o Instituto Pasteur esteve na vanguarda da luta contra as doenças infecciosas. Em 1983, este organismo internacional de investigação foi o primeiro a isolar o vírus da imunodeficiência humana (VIH), o vírus que causa a síndrome da imunodeficiência adquirida (SIDA). Ao longo dos anos, foi responsável por descobertas revolucionárias que permitiram à medicina controlar doenças virulentas como a difteria, o tétano, a tuberculose, a poliomielite, a gripe, a febre amarela, a peste epidémica, a hepatite B e a SIDA.

Plataforma

France Université Numérique est le diffuseur des cours en ligne des établissements d’enseignement supérieur français et de leurs partenaires.

Il opère plusieurs plateformes de diffusion, dont la plus connue, FUN MOOC, est la première plateforme académique francophone mondiale. Grâce à de nombreux établissements partenaires, cette plateforme propose un vaste catalogue de cours s’enrichissant de jour en jour avec des thématiques variées et d’actualité.
 

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