Informações principais
Sobre o conteúdo
More than a century ago, Elie Metchnikoff established the bases of cellular innate immunity when he discovered the mechanism of phagocytosis.
However, during most of the XXth century, adaptive immunity (also known as specific immunity) focused most of the interest of the researchers, until Charles Janeway and Polly Matzinger revisited the definition of immunology. What was called “non-specific immunity” was renamed “innate immunity”, and the understanding of the sensing of the exogenous or endogenous dangers signals, and their identification revolutionized our understanding of the early mechanism aimed to defend the integrity of the host against any type of attacks including pathogens.
Nowadays, how bacteria, viruses, parasites and fungi are sensed by the infected host, have been mostly deciphered. Similarly, the mechanisms of the host involved to defend its integrity against infectious process have been decoded. This MOOC describes the players and the whole orchestra involved in innate immunity against pathogens.
At the end of this course, you will be able to:
- Define the cellular and molecular players of innate immunity,
- Describe the mechanisms that lead to the elimination of pathogens
- Explain the strategies of the pathogens against the innate immune system
- Discuss the influence of genetic and microbiota on innate immune system
- Present its links with central nervous system and adaptive immunity
Pré-requisito
This MOOC targets people with a medical or scientific training background who are interested in all aspects of innate immunity: medical students, scientific Master II and PhD students (Immunology, Bacteriology, Parasitology, Virology…), post-doc, physicians, pharmacists, veterinarians, and all scientists working on bacteria, viruses, fungi and parasites, interested to learn more about the defense mechanism of the host against their favored bug.
Programa de estudos
Chapter 1: Cellular players - part 1
Chapter 2: Cellular players - part 2
Chapter 3: Molecular players - part 1
Chapter 4: Molecular players - part 2
Chapter 5: Host-pathogen interactions
Chapter 6: Regulation of innate immune response
Instrutores
Jean-Marc Cavaillon
Jean-Marc Cavaillon got his Doctorat-ès-Sciences in 1980 (University of Paris VI). After completing his post-doctoral fellowship at the University of Toronto, he joined the Institut Pasteur (Paris). He is now professor and Head of the research Unit "Cytokines & Inflammation".
Daniel Scott-Algara
He is Director of Research in the Cytokines and Inflammation Unit and Head of the Innate Immunity team in the Pasteur Institute in Paris. He is working in Innate Immune responses against pathogens. He is conducting several basic and clinical researches in the role of innate immunity in the resistance or protection against viral diseases like HIV and Hepatitis.
Criador do conteúdo
O Institut Pasteur é uma fundação francesa privada, sem fins lucrativos, com sede em Paris, dedicada ao estudo da biologia, dos microrganismos, das doenças e das vacinas.
Criado em 1888 graças a uma subscrição pública internacional, tem o nome de Louis Pasteur1, o seu fundador e primeiro diretor, que em 1885 desenvolveu a primeira vacina contra a raiva.
Durante mais de um século, o Instituto Pasteur esteve na vanguarda da luta contra as doenças infecciosas. Em 1983, este organismo internacional de investigação foi o primeiro a isolar o vírus da imunodeficiência humana (VIH), o vírus que causa a síndrome da imunodeficiência adquirida (SIDA). Ao longo dos anos, foi responsável por descobertas revolucionárias que permitiram à medicina controlar doenças virulentas como a difteria, o tétano, a tuberculose, a poliomielite, a gripe, a febre amarela, a peste epidémica, a hepatite B e a SIDA.
Plataforma
France Université Numérique est le diffuseur des cours en ligne des établissements d’enseignement supérieur français et de leurs partenaires.
Il opère plusieurs plateformes de diffusion, dont la plus connue, FUN MOOC, est la première plateforme académique francophone mondiale. Grâce à de nombreux établissements partenaires, cette plateforme propose un vaste catalogue de cours s’enrichissant de jour en jour avec des thématiques variées et d’actualité.
