Informações principais
Sobre o conteúdo
Emerging and re-emerging viruses are key players among the different pathogens that have caused recent epidemics, as attested by several severe outbreaks affecting humans such as Ebola, chikungunya, influenza, Zika, dengue, SARS and MERS or outbreaks attacking animals such as rabies and bluetongue disease.
This MOOC aims to provide a fundamental knowledge about the different viruses that are involved in viral emergence and describes the associated molecular mechanisms and conditions that drive their emergence. Those range from viral mutations to climate change, the impact of urbanization to alterations in human behaviour.
Special attention is given to the global “One Health” approach. The MOOC also provides basic insights on viral epidemiology and outbreak modelling as well as on detection, early management and infection control mechanisms. It focuses on the scientific and medical measures to prevent and counteract the emergence or re-emergence of viruses, but it also brings a view about the response of governments and agencies such as the World Health Organization (WHO) to control the worldwide viral dissemination. The MOOC is built up on the profound expertise from international experts in the field of emerging and re-emerging viruses and takes advantage of the worldwide Institut Pasteur Network.
Finally, it should be emphasized that this MOOC illustrates the latest knowledge about the current SARS-CoV-2-Covid-19 pandemic. Here are presented data from Covid-19 virology, epidemiology and vaccinology, as well as the latest findings on the structural determinants of Covid-19 for the design of therapeutic monoclonal antibodies. The impact of Covid-19 infection on the central nervous system is also deciphered.
At the end of this course, you will be able to:
- learn about viruses involved in viral emergence and re-emergence,
- understand the molecular mechanisms and conditions favoring such emergence, such as climate change,
- master knowledge of virology, epidemiology, vaccinology, pathogenesis and therapy associated with the current Covid-19 pandemic.
Pré-requisito
We recommend a good scientific background (such as a bachelor of life science)./ Un bon niveau scientifique est recommandé pour suivre ce MOOC (licence en sciences de la vie).
Programa de estudos
Chapter 1 – Introduction
- W1-1: General Introduction
- W1-2: Definition: Emerging and re-emerging
- W1-3 : Principles : Vectors, Hosts, Reservoirs…
- W1-4: One Health (Hervé Bourhy, Institut Pasteur)
Chapter 2 – Molecular mechanisms that drive viruses to be emerging or re-emerging
- W2-1 : Newly identified viruses (Marc Eloit, Institut Pasteur)
- W2-2 : Avian Influenza (Jean-Claude Manuguerra, Institut Pasteur)
- W2-3: Previously known viruses that acquired additional virulence traits: Influenza viruses 1 and 2 (Sylvie van der Werf, Institut Pasteur)
- W2-4: Control of the host on the virus (Carla Saleh, Institut Pasteur)
Chapter 3 – Conditions that favor emergence or re-emergence of viruses
- W3-1: Changes in urbanization, human behavior (Pascal Handschumacher UNISTRA)
- W3-2: Changes in Climate, deforestation, Natural disasters(Joacim Rocklöv (Université d’Umea, Sweden)
- W3-3 : Coronavirus : SARS, MERS-CoV (Luis Enjuanes, Madrid)
- W3-4: Yellow Fever(Nolween Jouvenet, Institut Pasteur)
- W3-5: Hantavirus and Lassa Fever (Noel Tordo, Institut Pasteur)
- W3-6: Human-nonhuman primate contact as a driver of viral emergence (Tamara Gilles-Vernick)
- W3-7: A 20 year experience of Bluetongue circulation in Europe (Damien Vitour)
Chapter 4 – One health
- W4-1: Bornavirus diseases (Hilde Angermeier, Institut Pasteur EUPHEM)
- W4-2: Nipah Virus (Birgit Nikolai)
- W4-3: Dengue (Marie Flamand, Institut Pasteur)
- W4-4: Rift valley fever (Benjamin Brennan, Glascow)
- W4-5: Crimean-Congo virus (Claudia Filippone, Institut Pasteur Madagascar)
- W4-6: Hepatitis E (Nicole Pavio, ANSES Maisons-Alfort)
Chapter 5 : Epidemiology and Modelling
- W5-1: Phylogeny and viruses (Noël Tordo, Institut Pasteur)
- W5-2: Epidemiology of Zika (Arnaud Fontanet, Institut Pasteur)
- W5-3: Epidemiology of Hepatitis C in Egypt (Arnaud Fontanet, Institut Pasteur)
- W5-4: Ebola virus outbreak: From the field to the lab (Christophe Peyrefitte, Institut Pasteur Dakar)
- W5-5: Quasispecies and viruses (Esteban Domingo, Madrid)
- W5-6: Modelling the epidemiology of viral infection (Simon Cauchemez, Institut Pasteur)
Chapter 6 : Detection, Early management and infection control
- W6-1 : Surveillance of vectors (Norbert Becker, Heidelberg)
- W6-2 : Surveillance of viral diseases (Harold Noël, Santé Publique France)
- W6-3 : Molecular epidemiology (Antoine Gessain, Institut Pasteur)
- W6-4 : CIBU and Arboviruses (Jessica Vanhomwegen, Institut Pasteur)
Chapter 7 : Prevention and response
- W7-1: Vector control activities (Norbert Becker, Heidelberg)
- W7-2: Bioterrorism lessons from the past and Orthopoxvirus Antiviral strategy approach (Christophe Peyrefitte, Institut Pasteur Dakar)
- W7-3: Preparedness (Marie-Paule Kieny, Inserm)
- W7-4: Example: OITF of IP (Eileen Farnon/Amber Kunkel/Jean-Claude Manuguerra)
- W7-5: Public health response: from science to politics (Didier Houssin, DGS)
- W7-6: Vaccines (Frédéric Tangy, Institut Pasteur)
- W7-7: Therapeutics (Etienne Decroly, AFMB Polytech, Luminy)
- W7-8: WHO list of blueprint priority diseases (Marie-Paule Kieny, WHO)
Chapter 8 : Focus on SRAS-CoV2 - CoVid19
- W8-1 : Covid19 - Virology (Olivier Schwartz)
- W8-2 : Covid19 - Epidemiology (Arnaud Fontanet)
- W8-3 : Covid19 - Vaccinology (Christiane Gerke)
- W8-4 : Covid19 - Structure and Monoantibodies Therapy (Felix Rey)
- W8-5 : Covid19 - Covid19 and its impact on the CNS (Hervé Bouhry ou/et Guilherme Dias De Melo)
Instrutores
Jean-Pierre Vartanian
Jean-Pierre Vartanian is Associate Professor at Institut Pasteur (Molecular Retrovirology Unit). He is the co-director of the Fundamental Virology course at the Institut Pasteur. His work is focused on identifying restriction factors involved in viral replication and the role of cellular RNA/DNA editing enzymes with antiviral activity against a range of human pathogens.
Pierre-Emmanuel Ceccaldi
Pierre-Emmanuel Ceccaldi is Professor at Université de Paris and Team Leader in the Epidemiology and Pathophysiology of Oncogenic Viruses Unit, Institut Pasteur. He is the co-director of the Fundamental Virology course at the Institut Pasteur. His work is focused on the interactions of different viruses with host barriers (blood-brain barrier, intestinal barrier…), and neuromuscular system.
Hilde Angermeier
Hilde Angermeier is a microbiologist and post-doctoral fellow within the European Public Health Microbiology training program (EUPHEM) of the European Centre for Disease Prevention and Control (ECDC). She is based for these two years at Institut Pasteur in Paris, France, where she is involved in different surveillance, public health microbiology research, laboratory and outbreak investigation, biorisk and quality management as well as teaching projects. Her ongoing projects involve the characterization of novel Yersinia species, seroprevalence studies on Hantaviruses and Leptospira, the genomic investigation of a recurrent Salmonella outbreak in France as well as the evaluation of the performance of rabies diagnostic tests in the frame of the quality management system present in the National Reference Center (NRC) for rabies. In addition, she has been involved in teaching during a workshop on rabies diagnostic techniques in Zimbabwe and in the development of massive open-online courses (MOOCs) of the Institut Pasteur.
Criador do conteúdo
O Institut Pasteur é uma fundação francesa privada, sem fins lucrativos, com sede em Paris, dedicada ao estudo da biologia, dos microrganismos, das doenças e das vacinas.
Criado em 1888 graças a uma subscrição pública internacional, tem o nome de Louis Pasteur1, o seu fundador e primeiro diretor, que em 1885 desenvolveu a primeira vacina contra a raiva.
Durante mais de um século, o Instituto Pasteur esteve na vanguarda da luta contra as doenças infecciosas. Em 1983, este organismo internacional de investigação foi o primeiro a isolar o vírus da imunodeficiência humana (VIH), o vírus que causa a síndrome da imunodeficiência adquirida (SIDA). Ao longo dos anos, foi responsável por descobertas revolucionárias que permitiram à medicina controlar doenças virulentas como a difteria, o tétano, a tuberculose, a poliomielite, a gripe, a febre amarela, a peste epidémica, a hepatite B e a SIDA.
Plataforma
France Université Numérique est le diffuseur des cours en ligne des établissements d’enseignement supérieur français et de leurs partenaires.
Il opère plusieurs plateformes de diffusion, dont la plus connue, FUN MOOC, est la première plateforme académique francophone mondiale. Grâce à de nombreux établissements partenaires, cette plateforme propose un vaste catalogue de cours s’enrichissant de jour en jour avec des thématiques variées et d’actualité.
