Genome Sequencing (Bioinformatics II)

Welcome to class!

This course will focus on two questions at the forefront of modern computational biology, along with the algorithmic approaches we will use to solve them in parentheses:

1. Weeks 1-2: How Do We Assemble Genomes? (Grap...
2. Week 2 - Week 2: Applying Euler's Theorem to Assemble Genomes
   

   Welcome to Week 2 of class!

   This week in class, we will see how a 300 year-old mathematical theorem will help us assemble a genome from millions of tiny pieces of DNA.

3. Week 3 - Week 3: Sequencing Antibiotics
   

   Welcome to Week 3 of class!

   This week, we begin a new chapter, titled "How Do We Sequence Antibiotics?"  In this chapter, we will learn how to determine the amino acid sequences making up antibiotics using brute force algorithms.

   B...

4. Week 4 - Week 4: From Ideal to Real Spectra for Antibiotics Sequencing
   

   Welcome to Week 4 of class!

   Last week, we discussed how to sequence an antibiotic peptide from an ideal spectrum. This week, we will see how to develop more sophisticated algorithms for antibiotic peptide sequencing that are able to handle spectra w...

5. Week 5 - Week 5: Bioinformatics Application Challenge!
   Welcome to Week 5 of class!This week, we will see how to apply genome assembly tools to sequencing data from a dangerous pathogenic bacterium.