link Source :
list 11 séquences
assignment Niveau : Introductif
chat_bubble_outline Langue : Anglais
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Les infos clés

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timer 33 heures de cours

En résumé

Introductory virology course emphasizing the common reactions that must be completed by all viruses for successful reproduction within a host cell.

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Le programme

Week 1
Welcome to virology
What is a virus?
Viruses then and now
Week 2
The infectious cycle
Assay of viral infectivity
Measurement of virions and their components
Revolutionary methods
One-step growth cycle
Week 3
The Baltimore scheme
DNA virus genomes
RNA virus genomes
Viral genetics
Week 4
The tools of structural virology
Helical symmetry
Icosahedral symmetry
Enveloped virions
Complex virions
Week 5
Attachment to cells
Entry into cells
Acid-catalyzed fusion
A new paradigm for entry
Entry of non-enveloped virions
Entering the nucleus
Week 6
Viral RNA synthesis
RNA polymerization
Plus strand RNA synthesis
Negative strand RNA synthesis
RNA synthesis of dsRNA genomes
RNA synthesis as a source of diversity
Week 7
DNA basics
Lessons from SV40
Priming via DNA or protein
Viral origins
Big DNA viruses
Regulation of DNA synthesis
Week 8
Initiation of transcription
Viral transcription regulation
Capping and polyadenylation
Pre-mRNA splicing
Week 9
Reverse transcriptase
Reverse transcription
The provirus
Hepatitis B virus
Week 10
End-dependent initiation of protein synthesis
Other decoding mechanisms
One mRNA, one protein?
Maximizing coding capacity of the viral genome
Regulation of translation: eIF2alpha
How viruses regulate cell translation
Week 11
Principles of virion assembly
Getting to the right place
Making sub-assemblies
Concerted assembly: Budding
Genome packaging
Acquisition of an envelope and egress

Les intervenants

  • Vincent Racaniello

Le concepteur

Columbia University
For more than 250 years, Columbia has been a leader in higher education in the nation and around the world. At the core of our wide range of academic inquiry is the commitment to attract and engage the best minds in pursuit of greater human understanding, pioneering new discoveries and service to society.

La plateforme


Coursera est une entreprise numérique proposant des formations en ligne ouverte à tous fondée par les professeurs d'informatique Andrew Ng et Daphne Koller de l'université Stanford, située à Mountain View, Californie.

Ce qui la différencie le plus des autres plateformes MOOC, c'est qu'elle travaille qu'avec les meilleures universités et organisations mondiales et diffuse leurs contenus sur le web.

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