Understanding Cancer Metastasis
list 3 séquences
assignment Niveau : Introductif
chat_bubble_outline Langue : Anglais
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Les infos clés

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timer 15 heures de cours

En résumé

Over 500,000 people in the United States and over 8 million people worldwide are dying from cancer every year. As people live longer, the incidence of cancer is rising worldwide, and the disease is expected to strike over 20 million people annually by 2030. Everyone has been, or will be touched by cancer in some way during their lifetime. Thanks to years of dedication and commitment to research we’ve made enormous advances in the prevention and treatment of cancer, But there is still a lot of work to be done. In this course, physicians and scientists at the Johns Hopkins School of Medicine explain how cancer spreads or metastasizes. We’ll describe the major theories of metastasis and then describe the biology behind the steps in metastasis. The course also describes the major organs targeted by metastasis and describes how metastases harm the patient.

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Le programme

  • Week 1 - History and Overview of Metastasis
    In this first module, we'll concentrate on the history and overview of metastasis and give you a flavor of how cancer is defined as well as some of the history surrounding how we began to understand metastasis.
  • Week 1 - Primary Tumor Growth and Neoangiogenesis
    In this module, we'll focus on uncontrolled cell division, which is a defining property of cancer, as well as mutation and neoangiogenesis and their roles in tumor formation. We'll also take a look at a primary tumor microenvironment and its component cell typ...
  • Week 2 - EMT / Invasion / Intravasation
    During this module, we'll turn our attention to the next steps after the initial primary tumor formation, epithelial to mesenchymal transition of cancer cells, and local tumor invasion and intravasation into blood or lymph vessels.
  • Week 2 - Survival in the Circulation and Extravasation
    We'll now take a close look at cancer survival within the circulation, the role of the circulatory system in metastasis, the genetic determinants of metastatic potential, signalling mechanisms, chemokines, the dock and lock hypothesis, and extravasation.
  • Week 3 - Dormancy and Secondary Tumor Growth
    In this module, we'll focus on dormancy and secondary tumor growth and how they contribute to the lethality of cancer.
  • Week 3 - Morbidity and Mortality Associated with Metastasis
    In the previous modules, we've looked closely at the sequential steps of metastasis and some of the biology of how metastasis occurs. Now, we'll turn our attention to morbidity and mortality, or in other words, how cancer hurts and kills people.
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Les intervenants

Kenneth Valkenburg
Prostate Cancer Researcher
The James Buchanan Brady Urological Institute

Jelani Zarif
Prostate Cancer Researcher
The James Buchanan Brady Urological Institute

Haley Axelrod
Prostate Cancer Researcher
The James Buchanan Brady Urological Institute

Sarah Amend
Prostate Cancer Researcher
The James Buchanan Brady Urological Institute

Kenneth J. Pienta, M.D.
The Donald S. Coffey Professor of Urology
The James Buchanan Brady Urological Institute

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Le concepteur

Johns Hopkins University
The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.
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La plateforme

Coursera

Coursera est une entreprise numérique proposant des formations en ligne ouverte à tous fondée par les professeurs d'informatique Andrew Ng et Daphne Koller de l'université Stanford, située à Mountain View, Californie.

Ce qui la différencie le plus des autres plateformes MOOC, c'est qu'elle travaille qu'avec les meilleures universités et organisations mondiales et diffuse leurs contenus sur le web.

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