Network Analysis in Systems Biology

Network Analysis in Systems Biology

Cours
en
Anglais
60 h
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Source
  • Sur www.coursera.org
Conditions
  • À son rythme
  • Accès libre
  • Certificat payant
Plus d'informations
  • 10 séquences
  • Niveau Introductif

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Détails du cours

Déroulé

  • Week 1 - Course Overview and Introductions
    The 'Introduction to Complex Systems' module discusses complex systems and leads to the idea that a cell can be considered a complex system or a complex agent living in a complex environment just like us. The 'Introduction to Biology for Engineers' module prov...
  • Week 2 - Topological and Network Evolution Models
    In the 'Topological and Network Evolution Models' module, we provide several lectures about a historical perspective of network analysis in systems biology. The focus is on in-silico network evolution models. These are simple computational models that, based o...
  • Week 3 - Types of Biological Networks
    The 'Types of Biological Networks' module is about the various types of networks that are typically constructed and analyzed in systems biology and systems pharmacology. This lecture ends with the idea of functional association networks (FANs). Following this ...
  • Week 4 - Data Processing and Identifying Differentially Expressed Genes
    This set of lectures in the 'Data Processing and Identifying Differentially Expressed Genes' module first discusses data normalization methods, and then several lectures are devoted to explaining the problem of identifying differentially expressed genes with t...
  • Week 5 - Gene Set Enrichment and Network Analyses
    In the 'Gene Set Enrichment and Network Analyses' module the emphasis is on tools developed by the Ma'ayan Laboratory to analyze gene sets. Several tools will be discussed including: Enrichr, GEO2Enrichr, Expression2Kinases and DrugPairSeeker. In addition, one...
  • Week 6 - Deep Sequencing Data Processing and Analysis
    A set of lectures in the 'Deep Sequencing Data Processing and Analysis' module will cover the basic steps and popular pipelines to analyze RNA-seq and ChIP-seq data going from the raw data to gene lists to figures. These lectures also cover UNIX/Linux commands...
  • Week 7 - Principal Component Analysis, Self-Organizing Maps, Network-Based Clustering and Hierarchical Clustering
    This module is devoted to various method of clustering: principal component analysis, self-organizing maps, network-based clustering and hierarchical clustering. The theory behind these methods of analysis are covered in detail, and this is followed by some pr...
  • Week 8 - Resources for Data Integration
    The lectures in the 'Resources for Data Integration' module are about the various types of networks that are typically constructed and analyzed in systems biology and systems pharmacology. These lectures start with the idea of functional association networks (...
  • Week 9 - Crowdsourcing: Microtasks and Megatasks
    The final set of lectures presents the idea of crowdsourcing. MOOCs provide the opportunity to work together on projects that are difficult to complete alone (microtasks) or compete for implementing the best algorithms to solve hard problems (megatasks). You w...
  • Week 10 - Final Exam
    The final exam consists of multiple choice questions from topics covered in all of modules of the course. Some of the questions may require you to perform some of the analysis methods you learned throughout the course on new datasets.

Prérequis

Aucun.

Intervenants

Avi Ma’ayan, PhD
Director, Mount Sinai Center for Bioinformatics
Professor, Department of Pharmacological Sciences

Éditeur

The Icahn School of Medicine at Mount Sinai, formerly the Mount Sinai School of Medicine, is an American medical school in the borough of Manhattan in New York City. The Graduate School of Biomedical Sciences provides rigorous training in basic science and clinical research.

Plateforme

Coursera est une entreprise numérique proposant des formations en ligne ouverte à tous fondée par les professeurs d'informatique Andrew Ng et Daphne Koller de l'université Stanford, située à Mountain View, Californie.

Ce qui la différencie le plus des autres plateformes MOOC, c'est qu'elle travaille qu'avec les meilleures universités et organisations mondiales et diffuse leurs contenus sur le web.

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