Introduction to Systems Biology
date_range Débute le 4 février 2019
event_note Se termine le 22 avril 2019
list 10 séquences
assignment Niveau : Introductif
chat_bubble_outline Langue : Anglais
language Sous titrage : Chinois
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Les infos clés

credit_card Formation gratuite
verified_user Certification payante
timer 60 heures de cours

En résumé

This course will introduce the student to contemporary Systems Biology focused on mammalian cells, their constituents and their functions. Biology is moving from molecular to modular. As our knowledge of our genome and gene expression deepens and we develop lists of molecules (proteins, lipids, ions) involved in cellular processes, we need to understand how these molecules interact with each other to form modules that act as discrete functional systems. These systems underlie core subcellular processes such as signal transduction, transcription, motility and electrical excitability. In turn these processes come together to exhibit cellular behaviors such as secretion, proliferation and action potentials. What are the properties of such subcellular and cellular systems? What are the mechanisms by which emergent behaviors of systems arise? What types of experiments inform systems-level thinking? Why do we need computation and simulations to understand these systems? The course will develop multiple lines of reasoning to answer the questions listed above. Two major reasoning threads are: the design, execution and interpretation of multivariable experiments that produce large data sets; quantitative reasoning, models and simulations. Examples will be discussed to demonstrate “how” cell- level functions arise and “why” mechanistic knowledge allows us to predict cellular behaviors leading to disease states and drug responses.

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Le programme

  • Week 1 - Systems Level Reasoning | Molecules to Pathways
    Module description goes here.
  • Week 2 - Pathways to Networks | Physical Forces and Electrical Activity in Cell Biology
    Module description goes here.
  • Week 3 - Mathematical Representations of Cell Biological Systems | Simulations of Cell Biological Systems
    Module description goes here.
  • Week 4 - Experimental Technologies | Network Building and Analysis
    Module description goes here.
  • Week 5 - Midterm
    Module description goes here.
  • Week 6 - Analysis of Networks | Topology to Function
    Module description goes here.
  • Week 7 - Strengths and Limitations of Different Types of Models | Identifying Emergent Properties
    Module description goes here.
  • Week 8 - Emergent Properties: Ultrasensitivity and Robustness | Case Studies
    Module description goes here.
  • Week 9 - Case Studies | Systems Biomedicine | Systems Pharmacology and Therapeutics | Perspective
    Module description goes here.
  • Week 10 - Final
    Module description goes here.

Les intervenants

Ravi Iyengar, PhD
Dorothy H. and Lewis Rosenstiel Professor
Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York (SBCNY)


Le concepteur

The Icahn School of Medicine at Mount Sinai, formerly the Mount Sinai School of Medicine, is an American medical school in the borough of Manhattan in New York City. The Graduate School of Biomedical Sciences provides rigorous training in basic science and clinical research.

La plateforme

Coursera est une entreprise numérique proposant des formations en ligne ouverte à tous fondée par les professeurs d'informatique Andrew Ng et Daphne Koller de l'université Stanford, située à Mountain View, Californie.

Ce qui la différencie le plus des autres plateformes MOOC, c'est qu'elle travaille qu'avec les meilleures universités et organisations mondiales et diffuse leurs contenus sur le web.

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