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分子生物学——原理与技术
Closed
Course
zh
Chinese
12 h
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- 3 Sequences
- Introductive Level
- Starts on September 29, 2015
- Ends on October 20, 2015
Course details
Syllabus
- 第一讲 生命之源，遗传信息的物质基础
- Lecture 1 分子生物学的前世今生 The past and present journey of molecular biology
- Lecture 2 揭秘遗传物质的化学本质The nature of genetic material
- Lecture 3 迷人的双螺旋Structure of DNA double strain helix
- Lecture 4 螺旋之螺旋——超螺旋的奥秘Supercoiled DNA
- Lecture 5 DNA的变性与复性与核酸杂交技术DNA Denaturation, renaturation and hybridization
- Lecture 6 核酸的提取及凝胶电泳 Nucleic acids extraction and gel electrophoresis
- 拓展学习资源 Learning resources
- 第二讲 浓缩的就是精华？ 从核苷酸到染色体
- Lecture 1 基因组不等于染色体 Genome not equals to chromosome
- Lecture 2 核小体及其组装Nucleosomes and their Assembly
- Lecture 3 更高级别的染色质结构Higher order chromatin structure
- Lecture 4 染色质修饰与重建Chromatin modification and remodeling
- 测试题 Tests
- 拓展学习资源 Learning resources
- 第三讲 谁与成双——DNA的复制
- Lecture 1 谁与成双——DNA的半保留复制 Semiconservative DNA replication
- Lecture 2 摊开你的掌心，让我看看你——DNA聚合酶The mechanism of DNA polymerase
- Lecture 3 团队协作的力量——DNA 复制的过程Process of DNA replication
- Lecture 4 DNA复制的起点及其调控Regulation of DNA replication initiation
- Lecture 5 真核细胞的DNA末端复制问题End replication problem of DNA in eukaryotic cell
- Lecture 6 我也来合成DNA Let’s “cook” DNA
- 测试题 Tests
- 拓展学习资源 Learning resources
- 第四讲 看我七十二变——DNA的损伤及修复
- Lecture 1 复制错了怎么办？Replication errors and the mismatch repair system
- Lecture 2 谁伤害了你的DNA？DNA damage
- Lecture 3 修复受损的DNA Repair of DNA damage
- Lecture 4 同源重组——不仅仅是拯救断裂的双链DNA Homologous Recombination
- Lecture 5 改变天然的基因序列 Changing the natural gene sequences
- 测试题 Tests
- 拓展学习资源 Learning resources
- 第五讲 读你千遍也不厌倦——原核细胞转录
- Lecture 1 谁能读懂基因的秘密：RNA聚合酶与转录概述RNA polymerase
- Lecture 2 原核细胞中的转录过程Transcription process in prokaryotes
- Lecture 3 原核细胞的转录调控I：乳糖操纵子 Lac operon
- Lecture 4 原核细胞的转录调控II：色氨酸操纵子Tryptophan operon
- 测试题 Tests
- 拓展学习资源
- 第六讲 我的世界只有你最懂——真核细胞的转录
- Lecture 1 真核细胞的RNA聚合酶及启动子Eukaryotic RNA polymerase and promoter
- Lecture 2 一个好汉三个帮：真核细胞基本转录过程Transcription process in eukaryotic cell
- Lecture 3 真核细胞转录激活因子Transcription factors of eukaryotic cell
- Lecture 4 基因表达的表观遗传调控Epigenetic Regulation of gene expression
- 测试题 Tests
- 拓展学习资源
- 第七讲 “我”不是原来的“我”—— RNA加工及转录后基因表达调控
- Lecture 1 不经历风雨，怎么见彩虹：RNA剪切RNA splicing
- Lecture 2 头上有犄角，身后有尾巴：前体mRNA的共转录加工 Cotranscriptional processing of nuclear pre-mRNA
- Lecture 3 一个基因一个蛋白？One gene one protein?
- Lecture 4 “看见”RNA “Seeing” RNA
- 测试题 Tests
- 拓展学习资源 Learning Resources
- 第八讲 我最爱读三字经
- Lecture 1 我最爱读三字经——遗传密码和解码器Genetic codons and ribosome
- Lecture 2 翻译过程Process of translation
- Lecture 3 精细永无止境：翻译水平的基因表达调控 Regulation of gene expression at Translational level
- Lecture 4 众里寻她千百度——找到你的目标蛋白Detect the location of certain protein
- 测试题 Tests
- 拓展学习资源 Learning resources
- 第九讲 我很强，因为我叫“分子生物技术”
- Lecture 1 遗传工程：给基因做个手术Genetic engineering: gene manipulation in vitro
- Lecture 2 窃取基因的秘密：基因克隆策略Gene cloning Strategies
- Lecture 3 我要找到你：重组体的筛选与鉴定Screening and identification of recombinants
- Lecture 4 服从命令听指挥：让咋表达咋表达 Let your gene expressed
- Lecture 5 想说爱你不容易：转基因植物Transgenic plants
- Lecture 6 养只荧光兔子做宠物：转基因动物Transgenic animals
- 测试题 Tests
- 拓展学习资源 Learning resources
- 第十讲 医生也该知道的分子生物技术
- Lecture 1 种棵摇钱树：基因工程药物Genetic engineering therapeutic products
- Lecture 2 谁让肿瘤细胞横行霸道？Molecular biology of cancer
- Lecture 3 用基因来“算命”：基因诊断与基因指纹Gene diagnosis and DNA fingerprints
- Lecture 4 修复“坏”基因：基因治疗Gene therapy
- 测试题 Tests
- 拓展学习资源
- 期末测试
- 期末测试题
- 讨论区得分
Prerequisite
None.
Instructors
- 卢晓云
Platform
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