Key Information
About the content
Introductory virology course emphasizing the common reactions that must be completed by all viruses for successful reproduction within a host cell.
Syllabus
Welcome to virology
What is a virus?
Viruses then and now
Week 2
The infectious cycle
Assay of viral infectivity
Measurement of virions and their components
Revolutionary methods
One-step growth cycle
The Baltimore scheme
DNA virus genomes
RNA virus genomes
Viral genetics
Structure
The tools of structural virology
Helical symmetry
Icosahedral symmetry
Enveloped virions
Complex virions
Attachment to cells
Entry into cells
Acid-catalyzed fusion
A new paradigm for entry
Entry of non-enveloped virions
Entering the nucleus
Viral RNA synthesis
RNA polymerization
Plus strand RNA synthesis
Negative strand RNA synthesis
RNA synthesis of dsRNA genomes
RNA synthesis as a source of diversity
DNA basics
Lessons from SV40
Priming via DNA or protein
Viral origins
Big DNA viruses
Regulation of DNA synthesis
Transcription
Initiation of transcription
Viral transcription regulation
Capping and polyadenylation
Pre-mRNA splicing
Reverse transcriptase
Retroviruses
Reverse transcription
Integration
The provirus
Hepatitis B virus
End-dependent initiation of protein synthesis
Other decoding mechanisms
One mRNA, one protein?
Maximizing coding capacity of the viral genome
Regulation of translation: eIF2alpha
How viruses regulate cell translation
MicroRNAs
Principles of virion assembly
Getting to the right place
Making sub-assemblies
Concerted assembly: Budding
Genome packaging
Acquisition of an envelope and egress
Instructors
- Vincent Racaniello
Content Designer
Columbia University is a private university located in Morningside Heights, in the north-western part of the borough of Manhattan, in New York (United States). Its origins lie in King's College, founded in 1754 by King George II of Great Britain. It is one of the oldest institutions of higher learning in the United States and is part of the Ivy League group of eight of the country's oldest, most famous, most prestigious and most elitist universities.
Columbia is one of the most selective and prestigious universities in the world. The admission rate was 5.1% in 2019, comparable to Harvard and Stanford. Ranked first in the United States for research, it is sixth in the world (fourth in the United States) in the CUWR ranking of the world's top 1,000 universities and eighth in the Shanghai University Rankings.
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