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Understanding Cancer Metastasis
Course
en
English
15 h
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- Self-paced
- Free Access
- Fee-based Certificate
- 3 Sequences
- Introductive Level
Course details
Syllabus
- Week 1 - History and Overview of Metastasis
In this first module, we'll concentrate on the history and overview of metastasis and give you a flavor of how cancer is defined as well as some of the history surrounding how we began to understand metastasis. - Week 1 - Primary Tumor Growth and Neoangiogenesis
In this module, we'll focus on uncontrolled cell division, which is a defining property of cancer, as well as mutation and neoangiogenesis and their roles in tumor formation. We'll also take a look at a primary tumor microenvironment and its component cell typ... - Week 2 - EMT / Invasion / Intravasation
During this module, we'll turn our attention to the next steps after the initial primary tumor formation, epithelial to mesenchymal transition of cancer cells, and local tumor invasion and intravasation into blood or lymph vessels. - Week 2 - Survival in the Circulation and Extravasation
We'll now take a close look at cancer survival within the circulation, the role of the circulatory system in metastasis, the genetic determinants of metastatic potential, signalling mechanisms, chemokines, the dock and lock hypothesis, and extravasation. - Week 3 - Dormancy and Secondary Tumor Growth
In this module, we'll focus on dormancy and secondary tumor growth and how they contribute to the lethality of cancer. - Week 3 - Morbidity and Mortality Associated with Metastasis
In the previous modules, we've looked closely at the sequential steps of metastasis and some of the biology of how metastasis occurs. Now, we'll turn our attention to morbidity and mortality, or in other words, how cancer hurts and kills people.
Prerequisite
None.
Instructors
Kenneth Valkenburg
Prostate Cancer Researcher
The James Buchanan Brady Urological Institute
Jelani Zarif
Prostate Cancer Researcher
The James Buchanan Brady Urological Institute
Haley Axelrod
Prostate Cancer Researcher
The James Buchanan Brady Urological Institute
Sarah Amend
Prostate Cancer Researcher
The James Buchanan Brady Urological Institute
Kenneth J. Pienta, M.D.
The Donald S. Coffey Professor of Urology
The James Buchanan Brady Urological Institute
Editor
Johns Hopkins University (JHU) is a private American university located in Baltimore, Maryland. It also has campuses in Washington, D.C. Bologna, Italy, Singapore and Nanjing, China. It owes its name to Johns Hopkins, a wealthy entrepreneur who bequeathed 7 million dollars to the university on his death.
One of the most prestigious universities in the United States (especially for its faculties of medicine and public health, as well as its school of international affairs), the institution defines itself as the country's leading "research university". At the beginning of its history, it was mainly inspired by the University of Heidelberg and the German educational model of Wilhelm von Humboldt. In 2019, 39 Nobel Prize winners have their names associated with the university.
Platform
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