Principles of Biomanufacturing: Using Biotechnology to Manufacture Medicines

Principles of Biomanufacturing: Using Biotechnology to Manufacture Medicines

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Course
en
English
18 h
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  • Self-paced
  • Course from 199 €
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  • 6 Sequences
  • Introductive Level

You can't access an archived course

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Course details

Syllabus

Course materials blend the following pedagogical strategies to best achieve the learning objectives of the course and individual modules:
  • Instructivism: Teacher-centered learning where the instructors present relevant content (tutorial videos enhanced with animation and graphics). Students will test their knowledge through graded tests.

  • Constructivism: Learning by doing approach. We encourage learners to construct their own understanding through solving the mandatory and optional case studies and practicing.

  • Social Constructivism: Learning through social interactions and communication. You will be able to discuss with your peers in the discussion groups, and evaluate and get reviews from your peers through two compulsory case studies.

  • Connectivism: Connecting with others and extending your knowledge through communication. You will be able to expand and share your knowledge with others through the Discussion group.


Week 1: Roadmap for Modern Biomanufacturing
  • Roadmap to Modern Biomanufacturing
  • Using Cells for Manufacturing
  • Proteins as Therapeutics
  • Course Structure and Expectations

Week 2: Protein Structure & Function
  • Protein Structure
  • Post Translational Modifications
  • Function Examples

Week 3: Cell Line Development
  • Design of DNA Vectors for Protein Expression
  • Selection of a Host for Production
  • Vector Design for Mammalian Hosts
  • Clonal Selection


Week 4: Upstream Bioreactors
  • Process Yield Calculation
  • Bioreactor Design Features
  • Mechanical Agitation
  • Upstream Process Development
  • Media Development

Week 5: Downstream Processing
  • Cell Harvest
  • Filtration Unit Operation
  • Depth Filtration
  • Ultrafiltration


Week 6: Downstream Processing & Regulation
  • Chromatography
  • Viral Clearance in Downstream Purification
  • Process Control, Process Validation, and Product Testing
  • Quality by Design
  • Manufacturing Process Variants

Prerequisite

The course is open to any interested participant. No advance reading is required. The faculty strongly recommend participants have a basic understanding of organic chemistry, calculus, and molecular biology.

Instructors

J. Christopher Love
Associate Professor of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT

Stacy L. Springs
Director of the Biomanufacturing Research Program (BioMAN)
MIT Center for Biomedical Innovation

Paul W. Barone
Associate Director of the Biomanufacturing Research Program (BioMAN)
MIT Center for Biomedical Innovation (CBI)

Platform

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