- Self-paced
- Course from 199 €
Principles of Biomanufacturing: Using Biotechnology to Manufacture Medicines
You can't access an archived course
- 6 Sequences
- Introductive Level
Course details
Syllabus
- Instructivism: Teacher-centered learning where the instructors present relevant content (tutorial videos enhanced with animation and graphics). Students will test their knowledge through graded tests.
- Constructivism: Learning by doing approach. We encourage learners to construct their own understanding through solving the mandatory and optional case studies and practicing.
- Social Constructivism: Learning through social interactions and communication. You will be able to discuss with your peers in the discussion groups, and evaluate and get reviews from your peers through two compulsory case studies.
- Connectivism: Connecting with others and extending your knowledge through communication. You will be able to expand and share your knowledge with others through the Discussion group.
Week 1: Roadmap for Modern Biomanufacturing
- Roadmap to Modern Biomanufacturing
- Using Cells for Manufacturing
- Proteins as Therapeutics
- Course Structure and Expectations
Week 2: Protein Structure & Function
- Protein Structure
- Post Translational Modifications
- Function Examples
Week 3: Cell Line Development
- Design of DNA Vectors for Protein Expression
- Selection of a Host for Production
- Vector Design for Mammalian Hosts
- Clonal Selection
Week 4: Upstream Bioreactors
- Process Yield Calculation
- Bioreactor Design Features
- Mechanical Agitation
- Upstream Process Development
- Media Development
Week 5: Downstream Processing
- Cell Harvest
- Filtration Unit Operation
- Depth Filtration
- Ultrafiltration
Week 6: Downstream Processing & Regulation
- Chromatography
- Viral Clearance in Downstream Purification
- Process Control, Process Validation, and Product Testing
- Quality by Design
- Manufacturing Process Variants
Prerequisite
Instructors
J. Christopher Love
Associate Professor of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Stacy L. Springs
Director of the Biomanufacturing Research Program (BioMAN)
MIT Center for Biomedical Innovation
Paul W. Barone
Associate Director of the Biomanufacturing Research Program (BioMAN)
MIT Center for Biomedical Innovation (CBI)
Platform
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