list 7 sequences
assignment Level : Intermediate
chat_bubble_outline Language : English
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Key informations

credit_card Free access
verified_user Fee-based Certificate
timer 42 hours in total

About the content

This medicinal chemistry course explores how chemists modify a molecule’s structure to design a safe and effective drug.

This course opens with a brief history of drug discovery and introduces the modern drug approval process.Then, we will transition to learning about receptors and enzymes, the body’s molecules most often targeted by drugs.We will also discuss the topics of pharmacokinetics (drug adsorption, elimination, and half-life) and metabolism. The course closes with units on how potential drug molecules are identified and subsequently optimized into safe and effective drugs.

  • How to measure the activity of enzymes and receptors
  • Methods for modeling a drug’s half-life
  • How to predict and alter the metabolism of a molecule
  • Techniques for discovering molecules with desired biological activity
  • Approaches for optimizing a molecule into a safe and effective drug

This course is offered through a collaboration between DavidsonX and the Novartis Institutes of BioMedical Research.

 

Courses offered via edX.org are not eligible for academic credit from Davidson College. A passing score in a DavidsonX course(s) will only be eligible for a verified certificate generated by edX.org.

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Prerequisite

High school level chemistry and biology and some experience with organic chemistry.
Basic math skills (logarithms and exponential functions) are also recommended.

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Syllabus

Week 1: Pre-Regulatory Medicine and the Drug Approval Process Early natural products and synthetic molecules used as drugs Safety issues in the first drugs Modern drug discovery and approval process Intellectual property issues with drugs  
Week 2: Drug Targets Structure of proteins Enzymes, enzymatic activity, and inhibition Receptors and molecules that modulate their activity Examination 1  
Week 3: Pharmacokinetics Drug transport in the blood Clearance Volume of distribution Compartment modeling  
Week 4: Metabolism Types of metabolic reactions Genetic and population effects Prodrugs Examination 2  
Week 5: Binding, Structure, and Diversity Intermolecular forces Drug-target complementarity Molecular diversity and chemical libraries Combinatorial chemistry  
Week 6: Lead Discovery Drug screening Filtering hits to find leads Existing drugs and natural products as leads  
Week 7: Lead Optimization Functional group replacements Alkyl group replacements Isosteres and bioisosteres Peptidomimetics Examination 3  
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Intructors

Erland Stevens
Faculty, Chemistry
Davidson College

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Content designer

Davidson College
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Platform

Harvard University, the Massachusetts Institute of Technology, and the University of California, Berkeley, are just some of the schools that you have at your fingertips with EdX. Through massive open online courses (MOOCs) from the world's best universities, you can develop your knowledge in literature, math, history, food and nutrition, and more. These online classes are taught by highly-regarded experts in the field. If you take a class on computer science through Harvard, you may be taught by David J. Malan, a senior lecturer on computer science at Harvard University for the School of Engineering and Applied Sciences. But there's not just one professor - you have access to the entire teaching staff, allowing you to receive feedback on assignments straight from the experts. Pursue a Verified Certificate to document your achievements and use your coursework for job and school applications, promotions, and more. EdX also works with top universities to conduct research, allowing them to learn more about learning. Using their findings, edX is able to provide students with the best and most effective courses, constantly enhancing the student experience.

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