Life in the Universe: Syntheses for Life
link Source: www.edx.org
date_range Starts on July 5, 2022
event_note Ends on August 10, 2022
list 5 sequences
assignment Level : Introductory
chat_bubble_outline Language : English
language Subtitles : Korean
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Key Information

credit_card Free access
verified_user Fee-based Certificate
timer 10 hours in total

About the content

“Syntheses for Life” will start with the Bohr model of hydrogen atom and discuss chemical evolution, protein synthesis and structure, photosynthesis, and Haber’s synthesis of ammonia. The course provides an overview of remarkable scientific discoveries. First, In 1913 Bohr showed that the hydrogen line spectrum can be explained based on the nuclear model of the atom and quantum theory. Bohr model introduced the concept of energy levels for electrons in an atom and led to wave mechanics and a full understanding of chemical bonding.

We will then discuss how amino acids could be produced from methane, ammonia, water and hydrogen using electric discharge as a source of energy. Chromatographic separation of simple compounds will be demonstrated. The 1953 paper in Science by Miller will be the primary source material. Third, The central dogma in protein synthesis will be briefly described. The determination of the primary structure of insulin will be discussed using Sanger’s 1958 Nobel Lecture. Experimental techniques such as electrophoresis and mass spectrometry as well as X-ray crystallography will be highlighted.

We focus on the chemical principles of oxidation and reduction in photosynthesis. Calvin’s 1961 Nobel Lecture explains the role of enzymes involved in the dark reaction. How plant life and animal life are coupled by photosynthesis and respiration will be emphasized. Finally, Haber’s synthesis of ammonia is on top of the list among scientific discoveries that saved most lives. How Haber successfully selected the right process conditions and the catalyst will be described using his 1918 Nobel Lecture. Ertl’s discovery of the mechanism of the iron catalyst will also be discussed.

  • How octet rule can be explained based on the electronic structure of atoms
  • How amino acids essential for life could be made from inorganic substances
  • How protein structure can be determined
  • How synthesis of ammonia saved many lives

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Syllabus

  • Week 1: Bohr model
  • Week 2: Chemical evolution
  • Week 3: Protein structure
  • Week 4: Photosynthesis
  • Week 5: Synthesis of ammonia
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Instructors

Hie-Joon Kim
Professor Emeritus, Department of Chemistry
Seoul National University

Tony Cho
TA
Seoul National University

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Content Designer

Seoul National University
Seoul National University
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