Human Population and Evolutionary Genetics
date_range Starts on November 12, 2019
event_note End date December 17, 2019
list 26 sequences
assignment Level : Introductive
chat_bubble_outline Language : English
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We recommend a good scientific background (such as a bachelor of live science)./ Une formation scientifique de type licence en Sciences de la Vie est recommandée.



Chapter 1 – Human genome diversity and population genetics/ Diversité du génome humain et génétique des populations

  • - Diversity of the human genome/Diversité du génome humain
  • - Public databases of population genetic variation/Bases de données de variations génétiques des populations
  • - Public engagement and return to populations/Engagement public et retour aux populations
  • - Causes of genetic diversity: mutation and recombination/Facteurs déterminant la diversité génétique: mutation et recombinaison
  • - Factors driving genetic diversity: genetic drift/ Facteurs déterminant la diversité génétique : dérive génétique
  • - Factors driving genetic diversity: natural selection/ Facteurs déterminant la diversité génétique : sélection naturelle

Chapter 2 – The demographic history of human populations/L’histoire démographique des populations humaines Diversité du génome humain et génétique des populations

  • - Methods of demographic inference/Méthodes d’inférence démographique
  • - Population splits and admixture among humans/Séparations et métissages des populations humaines
  • - The genetic history of the African continent/Histoire génétique du continent Africain
  • - The genetic history of the European continent/Histoire génétique du continent Européen
  • - The genetic history of Asia, Australia and Oceania/Histoire génétique de l’Asie, l’Australie et l’Océanie
  • - The genetic history of the Americas/Histoire génétique des Amériques
  • - The use of pathogens as markers of human migrations/L’utilisation de pathogènes comme marqueurs des migrations humaines
  • - Inferring cultural practices through genetics/Inférence des pratiques culturelles à travers la génétique.

Chapter 3 – The adaptive history of human populations/Histoire de l’adaptation des populations humaines

  • - Diversity of the human genome/Diversité du génome humain
  • - Methods to detect natural selection/Méthodes de détection de la sélection naturelle
  • - The effects of purifying selection in the genome and populations/Les effets de la sélection purificatrice sur le génome des populations humaines
  • - Adaptation to nutritional resources/Adaptation aux ressources nutritionnelles
  • - Adaptation to climate and extreme conditions/Adaptation au climat et aux conditions extrêmes
  • - Adaptation to pathogens and infectious diseases/Adaptation aux agents pathogènes et aux maladies infectieuses
  • - Alternative models of adaptation/Les modèles alternatifs de l’adaptation

Chapter 4 – The contribution of ancient DNA studies to human evolution/Contribution de l’étude de l’ancien ADN à l’évolution humaine

  • - Methods in ancient genomics/Méthodes en paléogénomique
  • - The archaic hominins and admixture with modern humans/Les homininés archaïques et leur métissage avec les humains modernes
  • - Recent history through the lens of ancient DNA/Histoire récente à travers la loupe de l’ADN ancien
  • - The phenotypic legacy of archaic admixture/L’héritage phénotypique du métissage archaïque
  • - The adaptive nature of archaic introgression/La nature adaptative de l’introgression archaïque


Lluis Quintana-Murci
Lluis Quintana-Murci received his BSc in Biology at the University of Barcelona (Spain), and his Ph.D. in Population Genetics at the University of Pavia (Italy). He heads the Unit of Human Evolutionary Genetics at Institut Pasteur since 2007. He is a human population geneticist whose research focuses on the use of genomic data to infer the past demographic history of human populations and to dissect the different forms in which natural selection can act on the human genome. His team is especially interested in exploring the extent to which pathogens have exerted pressures on innate immunity genes. Over the last years, his team has also adopted a systems immunology approach to understand the different factors (genetic, epigenetic, environmental, etc.) that drive immune response variation between individuals and populations. Lluis Quintan-Murci is professor at College de France.

Etienne Patin
Etienne Patin received his MSc in Biology and Genetics and his PhD in Population Genetics at the University Paris VII (France). After a postdoctoral training in epidemiological genetics at the Necker Hospital (France), he joined Institut Pasteur as a CNRS Research Scientist. He is a population geneticist whose main interests range from the study of past human demography, with a focus on Africa, to the methodological aspects of demographic inference, and, more recently, systems immunology. One of his main research interests is the occurrence and extent of admixture between modern human populations and its potential adaptive nature.


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Institut Pasteur

The Institut Pasteur is a non-profit private French foundation dedicated to the study of biology, microorganisms, diseases and vaccines.




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