Human Population and Evolutionary Genetics

Human Population and Evolutionary Genetics

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Course
en
English
10 h
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Source
  • From www.fun-mooc.fr
More info
  • 5 Sequences
  • Intermediate Level
  • Starts on October 16, 2023
  • Ends on December 5, 2023

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Course details

Syllabus

Chapter 1 – Human genome diversity and population genetics

  • Diversity of the human genome
  • Public databases of population genetic variation
  • Causes of genetic diversity: mutation and recombination
  • Factors driving genetic diversity: genetic drift
  • Factors driving genetic diversity: natural selection

Chapter 2 – The demographic history of human populations

  • Methods of demographic inference
  • Population splits and admixture among humans
  • The genetic history of the African continent
  • The genetic history of the European continent
  • The genetic history of Asia, Australia and Oceania
  • The genetic history of the Americas
  • The use of pathogens as markers of human migrations
  • Inferring cultural practices through genetics

Chapter 3 – The adaptive history of human populations

  • Diversity of the human genome
  • Methods to detect natural selection
  • The effects of purifying selection in the genome and populations
  • Adaptation to nutritional resources
  • Adaptation to climate and extreme conditions
  • Adaptation to pathogens and infectious diseases
  • Alternative models of adaptation

Chapter 4 – The contribution of ancient DNA studies to human evolution

  • Methods in ancient genomics
  • The archaic hominins and admixture with modern humans
  • Recent history through the lens of ancient DNA
  • The adaptive nature of archaic introgression
  • Public engagement and return to populations

 

 

Prerequisite

We recommend a good scientific background (such as a bachelor of live science).

Instructors

Lluis Quintana-Murci
Lluis Quintana-Murci received his BSc in Biology at the University of Barcelona (Spain), and his Ph.D. in Population Genetics at the University of Pavia (Italy). He heads the Unit of Human Evolutionary Genetics at Institut Pasteur since 2007. He is a human population geneticist whose research focuses on the use of genomic data to infer the past demographic history of human populations and to dissect the different forms in which natural selection can act on the human genome. His team is especially interested in exploring the extent to which pathogens have exerted pressures on innate immunity genes. Over the last years, his team has also adopted a systems immunology approach to understand the different factors (genetic, epigenetic, environmental, etc.) that drive immune response variation between individuals and populations. Lluis Quintan-Murci is professor at College de France.

Etienne Patin
Etienne Patin received his MSc in Biology and Genetics and his PhD in Population Genetics at the University Paris VII (France). After a postdoctoral training in epidemiological genetics at the Necker Hospital (France), he joined Institut Pasteur as a CNRS Research Scientist. He is a population geneticist whose main interests range from the study of past human demography, with a focus on Africa, to the methodological aspects of demographic inference, and, more recently, systems immunology. One of his main research interests is the occurrence and extent of admixture between modern human populations and its potential adaptive nature.

Javier Mendoza Revilla
Javier is a doctor in human genetics, researcher in the Genetics of Human Evolution unit of the Pasteur Institute and member of the CANDELA consortium. He is your community manager for this MOOC.

Editor

The Institut Pasteur is a private, not-for-profit French foundation based in Paris, dedicated to the study of biology, micro-organisms, diseases and vaccines.

Created in 1888 thanks to an international public subscription, it is named after Louis Pasteur1, its founder and first director, who in 1885 developed the first vaccine against rabies.

For over a century, the Institut Pasteur has been at the forefront of the fight against infectious diseases. In 1983, this international research organisation was the first to isolate the human immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS). Over the years, it has been responsible for revolutionary discoveries that have enabled medicine to control virulent diseases such as diphtheria, tetanus, tuberculosis, poliomyelitis, influenza, yellow fever, epidemic plague, hepatitis B and AIDS.

Platform

France Université Numérique is the broadcaster of the online courses of French higher education institutions and their partners.

It operates several platforms of diffusion, of which the best known, FUN MOOC, is the first French-speaking academic platform worldwide. Thanks to many partner institutions, this platform offers a vast catalog of courses enriched daily with various themes and current events.

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