Key Information
About the content
Please note: This course was developed in 2014. This course is not actively moderated by course instructors, please use the course forums to collaborate with other learners. Knowledge linking genomics to health and disease is rapidly expanding. Translation of this knowledge into clinical and public health practice offers promising opportunities but also raises a host of ethical, legal, social, and policy questions. Using case examples, this inter-disciplinary course will explore the challenges of genomic and precision medicine. This seven week, inter-disciplinary course provides an introduction to ethical, legal, social, and policy issues that arise in the translation of genomic knowledge into medical and public health practice. It considers challenges in health related and reproductive testing/screening focusing on six specific areas: • Pre‐conception genetic diagnosis, and prenatal testing/screening • Newborn screening • Use of genomic sequencing technologies to diagnose and predict disease • Targeting genomic testing/screening by race/ethnicity • Direct‐to‐consumer genomic testing/screening • Use of “big data” for genomic research and genomic translation Course Objectives 1. Critique the promise of genomics and precision medicine for improving health outcomes for individuals and populations. 2. Through analysis of key cases, demonstrate an understanding of the ethical, legal, social, and policy (ELSI) challenges that accompany the translation of new genomic knowledge into clinical medicine and public health practice. 3. Apply a critical analysis of ELSI concerns to your professional practice (if relevant), your interest as a potential user of genomic knowledge, and as a citizen with a responsibility to shape health policy.
Syllabus
Week 2: Reproductive Genetics
Week 3: Screening
Week 4: Genetic Technology in the Prediction and Diagnosis of Disease
Week 5: Race and Genetics
Week 6: Direct-to-Consumer Testing
Week 7: Where Do We Go From Here?
Instructors
Wylie Burke, MD, PhD
Professor, Department of Bioethics and Humanities, University of Washington
2013-14 Presidential Chair, University of California, San Francisco
Barbara A. Koenig, PhD
Professor of Medical Anthropology & Bioethics
Dept. of Social & Behavioral Sciences, Institute for Health & Aging, & Dept. of Anthropology, History, and Social Medicine
Julie N. Harris-Wai, Ph.D., MPH
Assistant Adjunct Professor
Department of Behavioral and Social Sciences
Content Designer

The University of California, San Francisco, is dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and high-quality patient care. UC San Francisco is the only campus in the University of California system dedicated exclusively to the health sciences. UCSF's innovative, collaborative approaches for health care, research and education span disciplines across the health sciences and make it a world leader in scientific discovery and its translation into improved health.
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