Epigenetics

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7 h
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  • From www.fun-mooc.fr
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  • Free Access
  • Free certificate
More info
  • 27 Sequences
  • Advanced Level
  • Subtitles in French, English
  • Starts on July 7, 2019
  • Ends on December 30, 2019

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Course details

Syllabus

Chapter 1: Fundamental principles about epigenetics/ Chapitre 1 : Principes fondamentaux de l’épigénétique.

  • Why is epigenetics a new frontier in biology?/ Pourquoi l’épigénétique est une nouvelle frontière en biologie?
  • From genetics to epigenetics: why do we need epigenetics to fully explain heritability?/ De la génétique à l’épigénétique: pourquoi avons-nous besoin de l’épigénétique pour expliquer complètement l’hérédité?
  • What should we consider to be epigenetics?/ Que doit on considerer comme de l’épigénétique?.

Chapter 2: The mechanisms and molecules that regulate epigenetic processes./ Chapitre 2: Les mécanismes et les molecules qui régulent les processus épigénétiques..

  • Epigenetic chromatin modifications: how multiple varieties of chemical modifications decorate the epigenome and its activity?/ Modifications épigénétiques de la chromatine: comment une grande variété de modifications chimiques dessinent l’épigénome et son activité?
  • DNA methylation and its fundamental role in epigenetic gene silencing. / La déméthylation de l’ADN et son rôle fondamental dans le silençage génique.
  • Regulation of epigenetic processes by non-coding RNAs./ Régulation des processus épigénétiques par des ARN non codants.
  • Dynamic organization of the genome and its impact on gene regulation and epigenetic processes./ Organisation dynamique du génome et son impact sur la régulation des gènes et les processus épigénétiques..

Chapter 3: Epigenetic phenomena in different model organisms, what can we learn from them?/Chapitre 3: L’épigénétique dans différents organismes. Que pouvons nous en apprendre?

  • X chromosome inactivation in Mammals./ L’inactivation du chromosome X chez les mamifères.
  • - Transgenerational epigenetic inheritance in animals./ L’héritage épigénétique transgénérationnel chez l’animal.
  • Epigenetic inheritance in plants./ Héritage épigénétique chez les plantes.
  • Epigenetic processes in fungi./ Héritage épigénétique chez les champignons.

Chapter 4: How can epigenetics influence the life of an organism?/ Chapitre 4: Comment l’épigénétique peut influencer la vie d’un organisme?

  • Inheritance of chromatin modifications at the beginning of life./ Héritage des modifications de chromatine au début de la vie.
  • Epigenetic reprogramming and genomic imprinting. / Reprogrammation épigénétique et empreinte génomique.
  • Role of epigenetic mechanisms during cell differentiation. / Rôle des mécanismes épigénétiques lors de la différenciation cellulaire.
  • Epigenetic variations in human populations./ Variations épigénétiques dans les populations humaines.-

Chapter 5: Environmental epigenetics, how environmental changes influenceheritability?/ Chapitre 5: Epigénétique environnementale. Comment les modifications de l’environnement influence l’héritabilité?

  • How nutrition drives heritable epigenetic changes? / Comment la nutrition conduit à des modifications épigénétiques héréditaires?
  • Epigenetic inheritance of environmental stresses./ Hérédité épigénétique du stress environnemental.
  • Epigenetic control of selfish elements during environmental changes. / Contrôle épigénétique des éléments génétiques égoïstes durant les modifications de l’environnement.

Chapter 6: Epigenetic mechanisms in diseases./ Chapitre 6: Mécanismes épigénétiques des maladies.

  • Epigenetic memory of bacterial infection./ Mémoire épigénétique des infections bactériennes.
  • Epigenetics and aging./ Epigénétique et vieillissement.
  • Epigenetic mechanisms in metabolic diseases./ Mécanismes épigénétiques dans les maladies métaboliques.
  • Role of DNA methylation and epigenetic histone modifications in cancer./ Rôle de la méthylation de l’AND et des modifications épigénétiques de l’histone dans le cancer.
  • Therapeutic epigenetic approaches to cancer./ Approche épigénétique du traitement du cancer.

Chapter 7: Future perspective./ Chapitre 7: Perspectives.

  • What will be the new frontiers of epigenetic research? / Quelles seront les nouvelles frontières de l’épigénétique?
  • Implication of epigenetic discoveries for human society./ Implications de la découverte de l’épigénétique pour la société humaine.
  • What will be the new frontiers of epigenetic research? / Quelles seront les nouvelles frontières de l’épigénétique?
  • What will be the new frontiers of epigenetic research? / Quelles seront les nouvelles frontières de l’épigénétique?

Prerequisite

We recommend a good scientific background (such as a bachelor of science)./ Un bon niveau scientifique est recommandé pour suivre ce MOOC (licence en sciences).

Instructors

Germano Cecere
Germano Cecere received his BSc degree in Biotechnology from the University of Naples “Federico II” in Italy in 2004, and his Ph.D. from University of Rome “La Sapienza” in 2008. He started to work on RNA silencing phenomena and small RNAs during his graduate study in the laboratory of Dr. Carlo Cogoni. After completing his Ph.D., he joined the laboratory of Dr. Alla Grishok at Columbia University for his postdoctoral work. There, he studied chromatin- and RNA-mediated epigenetic mechanisms, using C. elegans as a model organism. He is currently the head of the “Mechanisms of epigenetic inheritance” team at Institute Pasteur in Paris, in the Department of Developmental and Stem Cell Biology. His main interest is in studying how epigenetic information is propagated across generations and in exploring the role of inherited small RNAs in the transmission of traits across generations.

Editor

The Institut Pasteur is a private, not-for-profit French foundation based in Paris, dedicated to the study of biology, micro-organisms, diseases and vaccines.

Created in 1888 thanks to an international public subscription, it is named after Louis Pasteur1, its founder and first director, who in 1885 developed the first vaccine against rabies.

For over a century, the Institut Pasteur has been at the forefront of the fight against infectious diseases. In 1983, this international research organisation was the first to isolate the human immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS). Over the years, it has been responsible for revolutionary discoveries that have enabled medicine to control virulent diseases such as diphtheria, tetanus, tuberculosis, poliomyelitis, influenza, yellow fever, epidemic plague, hepatitis B and AIDS.

Platform

France Université Numérique is the broadcaster of the online courses of French higher education institutions and their partners.

It operates several platforms of diffusion, of which the best known, FUN MOOC, is the first French-speaking academic platform worldwide. Thanks to many partner institutions, this platform offers a vast catalog of courses enriched daily with various themes and current events.

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