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药物化学
Course
zh
Chinese
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- Introductive Level
Course details
Syllabus
- Start Here
- Welcome Videos
- Syllabus
- Survey
- Week 1
- Welcome to Week 1
- Chapter 1 - Pre-Regulatory Medicine
- 1.1 Natural Products
- 1.2 Synthetic Drugs
- 1.3 Need for Regulation
- Chapter 2 - Drug Discovery: From Concept to Market
- 2.1 Phenotype- and Target-Based Drug Discovery
- 2.2 Drug Discovery Outline
- 2.3 Intellectual Property
- Week 2
- Welcome to Week 2
- Chapter 3 - Protein Structure
- 3.1 Intro to Structure Pt 1
- 3.2 Intro to Structure Pt 2
- Chapter 4 - Enzymes
- 4.1 Michaelis-Menten Kinetics
- 4.2 Enzyme Inhibition
- 4.3 Measuring Inhibition
- Chapter 5 - Receptors
- 5.1 Types of Receptors
- 5.2 Ligands
- 5.3 Occupancy Theory
- Examination 1
- Week 3
- Welcome to Week 3
- Chapter 6 - Blood and Drug Transport
- 6.1 Blood
- 6.2 ADME
- Chapter 7 - Pharmacokinetics
- 7.1 IV Bolus
- 7.2 Clearance I
- 7.3 Clearance II
- 7.4 Volume of Distribution I
- 7.5 Volume of Distribution II
- 7.6 Oral Delivery I
- Survey
- Week 4
- Welcome to Week 4
- 7.7 Oral Delivery II
- 7.8 CL and Vd Revisited
- Chapter 8 - Metabolism
- 8.1 Introduction
- 8.2 Phase I Pt I
- 8.3 Phase I Pt II
- 8.4 Phase II
- 8.5 Metabolism Issues
- 8.6 Prodrugs
- Survey
- Examination 2
- Week 5
- Welcome to Week 5
- Chapter 9 - Binding, Structure, and Diversity
- 9.1 Intermolecular Forces
- 9.2 Case Study - Stromelysin
- 9.3 Drug-Target Complementarity
- 9.4 Molecular Diversity
- 9.5 Molecular Libraries
- 9.6 Building Libraries
- Survey
- Week 6
- Welcome to Week 6
- Chapter 10 - Lead Discovery
- 10.1 In Vitro Screening
- 10.2 Fragment Based Screening
- 10.3 Filtering Hits Pt 1
- 10.4 Filtering Hits Pt 2
- 10.5 Filtering Hits Pt 3
- 10.6 Selective Optimization of Side Activities
- 10.7 Natural Products
- Survey
- Week 7
- Welcome to Week 7
- Chapter 11 - Lead Optimization
- 11.1 Introduction
- 11.2 Functional Group Replacements
- 11.3 Alkyl Group Replacements
- 11.4 Isosteres
- 11.5 Directed Combinatorial Libraries
- 11.6 Peptidomimetics
- Examination 3
- Final Survey
- Thank You
- Testing (Rossi)
- Testing
Prerequisite
None.
Instructors
- Erland Stevens
Platform
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