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Comparing Genes, Proteins, and Genomes (Bioinformatics III)
Course
en
English
24 h
This content is rated 0 out of 5
- Self-paced
- Free Access
- Fee-based Certificate
- 6 Sequences
- Introductive Level
Course details
Syllabus
- Week 1 - Week 1: Introduction to Sequence Alignment
Welcome to class!
If you joined us in the previous course in this Specialization, then you became an expert at assembling genomes and sequencing antibiotics. The next natural question to ask is how to compare DNA and amino acid sequences. T...
- Week 2 - Week 2: From Finding a Longest Path to Aligning DNA Strings
Welcome to Week 2 of the class!
Last week, we saw how touring around Manhattan and making change in a Roman shop help us find a longest common subsequence of two DNA or protein strings.
This week, we will study how to find a highest scoring ...
- Week 3 - Week 3: Advanced Topics in Sequence Alignment
Welcome to Week 3 of the class!
Last week, we saw how a variety of different applications of sequence alignment can all be reduced to finding the longest path in a Manhattan-like graph.
This week, we will conclude the current chapter by cons...
- Week 4 - Week 4: Genome Rearrangements and Fragility
Welcome to Week 4 of the class!
You now know how to compare two DNA (or protein) strings. But what if we wanted to compare entire genomes? When we "zoom out" to the genome level, we find that substitutions, insertions, and deletions don't tell...
- Week 5 - Week 5: Applying Genome Rearrangement Analysis to Find Genome Fragility
Last week, we asked whether there are fragile regions in the human genome. Then, we took a lengthy detour to see how to compute a distance between species genomes, a discussion that we will continue this week.
It is probably unclear how computing th...
- Week 6 - Week 6: Bioinformatics Application Challenge
In the sixth and final week of the course, we will apply sequence alignment algorithms to infer the non-ribosomal code.
Prerequisite
None.
Instructors
Pavel Pevzner
Professor
Department of Computer Science and Engineering
Phillip Compeau
Visiting Researcher
Department of Computer Science & Engineering
Nikolay Vyahhi
Visiting Scholar
Department of Computer Science and Engineering
Editor
The University of California, San Diego is a public land-grant research university in San Diego, California. Established in 1960 near the pre-existing Scripps Institution of Oceanography, UC San Diego is the southernmost of the University of California's ten campuses and offers more than 200 undergraduate and graduate degree programs, enrolling 33,096 undergraduate students and 9,872 graduate students.
UC San Diego is considered one of the best universities in the world. Several publications have ranked UC San Diego's Departments of Biological Sciences and Computer Science among the top 10 in the world.
Platform
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